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전립선암에서 병기에 따른 혈청 산성인산효소의 진단적 유용성 - 혈청 전립선 특이항원과의 비교

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Author(s)
강주호김천일이성준Joo Ho KangChun Il KimSung Choon Lee
Keimyung Author(s)
Kim, Chun IlLee, Sung Joon
Department
Dept. of Urology (비뇨의학)
Institute for Medical Science (의과학연구소)
Journal Title
대한비뇨기과학회지
Issued Date
1997
Volume
38
Issue
11
Abstract
Purpose: To evaluate the clinical usefulness of PAP in staging and monitoring of patient with prostate cancer, we performed a comparative study with PSA, retrospectively. Methods: We evaluated 72 patients with prostate cancer. Of these patients 11 had stage A, 6 stage B, 10 stage C, 5 stage D1 and 40 stage D2 prostate cancer. Serum PAP level was measured in all 72 patients and serum PSA level was measured concomitantly in 42 patients. Results: The mean initial PAP value was 13.40+- 7.00 U/L. But only 40 (55.6%) had elevated PAP value above 1.5U/L at presentation. Of 55 advanced cases (stage C, D), 39 (76.9%) had elevated PAP values. Of the 42 patients, who underwent longitudinal PSA assessment, the mean initial PSA value was 178.0 +- 33.3 ng/ml. Forty (95.2%) had elevated PSA value above 4 ng/ml at presentation. Of 41 advanced cases (stage C, D1, D2), 33 (80.5%) exceeded 50 ng/ml. None of the patient had elevated PAP value with normal PSA value at presentation. Among 42 patients, who had followed with longitudinal serum PSA and PAP, progression of the disease to the bone, lung, and rectum occurred in 26 patients; in all PSA was the first indicator of progression and in none of them PAP anticipated PSA elevation. Conclusions: Although PAP value usually reflects advanced prostate cancer (70.9%), serum PSA also reflects it (80.5%). Serum PSA monitoring is superior to serum PAP monitoring in predicting disease progression. The use of PSA and PAP jointly to stage and monitor prostate cancer did not appear to enhance the clinical utility over that of PSA alone.
Key word : prostate specific antigen, prostatic acid phosphatase, prostate cancer
Alternative Title
Clinical Usefulness of Prostatic Acid Phosphatase in Prostate Cancer : A Comparative Study with Prostate Specific Antigen
Keimyung Author(s)(Kor)
김천일
이성준
Publisher
School of Medicine
Citation
강주호 et al. (1997). 전립선암에서 병기에 따른 혈청 산성인산효소의 진단적 유용성 - 혈청 전립선 특이항원과의 비교. 대한비뇨기과학회지, 38(11), 1183–1189.
Type
Article
ISSN
2005-6737
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38791
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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