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전립선암의 치료에서 간헐적 남성호르몬 차단요법의 효과: 주기별 변화 및 특징

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Author(s)
김정현박철희김천일Jung Hyun KimChoal Hee Park, Chun Il Kim
Keimyung Author(s)
Park, Choal HeeKim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
대한비뇨기과학회지
Issued Date
2002
Volume
43
Issue
5
Abstract
Purpose: The purpose of this study was to evaluate cycling change and characteristics of treatment in patients receiving intermittent androgen suppression (IAS).
Materials and Methods: From May 1995 to April 2001, we retrospectively reviewed 28 cases of prostate cancer patients treated with IAS. Treatment was initiated with goserelin acetate with flutamide and continued until serum PSA nadir was observed. Medication was then withheld till the serum PSA increased to a predetermined level. This cycle of treatment and no-treatment was repeated until the regulation of PSA became androgen independent.
Results: Patients have completed at least one, and up to four treatment cycles. Mean nadir serum PSA level was 0.69ng/ml, 0.70ng/ml, 1.15ng/ml, 2.64ng/ml for each cycle, and was reached within average 4.7 (2-8) months after beginning treatment. Patients spent an average of 42% of the time not receiving therapy, but the time off therapy decreased as the number of treatment cycles increased. In most cases, side effects related with androgen suppression was improved during off-treatment.
Conclusions: IAS appears to be a possible treatment option in patients with prostate cancer. This approach could result in reduced toxicity and cost of treatment and affords an improved quality of life when the patient is off therapy. (Korean J Urol 2002; 43:386-390)
Alternative Title
Effects of Intermittent Androgen Suppression in the Treatment of Prostate Cancer: Cycling Changes and Characteristics
Keimyung Author(s)(Kor)
박철희
김천일
Publisher
School of Medicine
Citation
김정현 et al. (2002). 전립선암의 치료에서 간헐적 남성호르몬 차단요법의 효과: 주기별 변화 및 특징. 대한비뇨기과학회지, 43(5), 386–390.
Type
Article
ISSN
2005-6737
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38793
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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