진통중 정상 만삭 임신부와 자간전증 임신부에서 혈장 Endothelin치의 비교

Abstract

To compare the maternal plasma endothelin level in normal pregnancies and preeclmpsia, 20 normotensive term pregnancy women and 53 preeclamptic women during first stage of labor at the Department of Obstetrics and Gynecology , Internal Medicine, School of Medicine, Keimyung University from January 1, 1993 to July 31, 1994 and 20 normal reproductive aged women as control group were studied. All preeclamptic pregnant women were treated with magnesium sulfate on admission. The plasma endothelin of control group , normotensive pregnant and preeclamptic were 20.03 +or-6.623 pg/ml, 24.09 +or- 9.20 gp/ml and 24.14 +or- 5.57 pg/ml, respectively. There was statistically significant elevation of endothelin in normotensive pregnant women during labor and preeclamptic women during labor compared with nonpregnant control group (p<0.05). No statistical difference of endothelin level was found between preeclampsia and normal pregnancy during first stage of labor. Above results may suggest that endothelin would be anticipated with parturition. But further studies should be needed about comparison without magnesium sulfate therapy in preeclamptic pregnant women and normal pregnant women with or without labor. Key word : Preeclampsia, Endothelin.