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전립선 암조직에서의 사람파필로마바이러스의 감염과 p53단백질의 발현에 대한 연구

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Author(s)
권두한진승원강병태윤희식유왕돈김현수이상숙이호자박순희Dur Han KwonSeung Won JinByung Tae KangHeesik YoonWang Don YooHyeun Soo KimSang Sook LeeHo Sa LeeSue Nie Park
Keimyung Author(s)
Lee, Sang Sook
Department
Dept. of Pathology (병리학)
Journal Title
대한바이러스학회지
Issued Date
1996
Volume
26
Issue
2
Abstract
Prostatic carcinoma is the leading second cause of cancer in men. Previous epidermiological studies implicated human papillomavirus as an infectious agent. Since there are only limited studies on the association of HPV to prosate cancer, we examined the prevalence of HPV infections in korean prostate cancer patients. We observed that out of 26 cases, 4 cases and 5 cases were infected by HPV 16(27%) and HPV 18 (31%), respectively and 3 cases by both (46%) and at least 18 were positive for HPV (69%). For these samples, immunohistochemical detection of the p53 and proliferative cell nuclear antigen (PCNA) were also studied, using monoclonal antibodies. Sixteen of 26 (61%) showed immunostaining for p53 protein. While 8 samples with no HPV infection (100%) showed all positive for p53 protein staining, less than half of the 18 patients with any HPV infection (44%) showed p53 protein staining. These findings indicate that altered expression of p53 protein occurs in the more than half of prostate cancers, however, p53 expression is less frequent in HPV infected tissues. This implies that there might be an inverse correlation in general between HPV infection and p53 amplification. However, while 50% (4 of 8) of HPV negative prostate cancer was positive for PCNA staining, 13 out of 18 HPV infected patients (72%) were positive. Therefore HPV infection is more strongly associated with increase proliferation. In addition HPV infected cancer patients are generally in more advanced status implying that HPV infection plays a role in the development of highly malignant prostatic carcinomas, eventhough the statistical significance of this interpretation might be waited for the analysis of more cases.
Key word : Human papillomavirus (HPV), p53, Proliferative Cell Nuclear Antigen (PCNA), Prostate Tissues.
Alternative Title
Human Papillomavirus Infections and p53 Expression in Prostatic Carcinoma
Keimyung Author(s)(Kor)
이상숙
Publisher
School of Medicine
Citation
권두한 et al. (1996). 전립선 암조직에서의 사람파필로마바이러스의 감염과 p53단백질의 발현에 대한 연구. 대한바이러스학회지, 26(2), 227–234.
Type
Article
ISSN
1225-2344
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38900
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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