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항경련제 중단 후 발작의 빈도 변화

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Author(s)
김성수이예이임정근이상도박영춘Sung Soo KimYeigh LeeJeong Geun LimSang Doe YiYoung Choon Park
Keimyung Author(s)
Lim, Jeong GeunYi, Sang DoPark, Young Chun
Department
Dept. of Neurology (신경과학)
Journal Title
대한신경과학회지
Issued Date
1997
Volume
15
Issue
3
Abstract
This study was performed to evaluate the effects of acute withdrawal of antiepileptic drugs in epileptic patients during continuous BEG monitoring. One hundred sixty-five withdrawals in 134 patients who were candidates for epileptic surgery were included for this study. Clinical features and frequency of seizure were observed after drug withdrawal with daily monitoring of serum drug level. The phases after withdrawal of antiepileptics were divided into phase of therapeutic drug level, phase of falling drug level, and phase of subtherapeutic or undetectable(zero) drug level. There were significant increase in frequency of seizure and seizure of secondary generalization after acute withdrawal of antiepileptic drugs. Number of seizure during the period of drugs withdrawals was not correlated with onset age of epilepsy, duration of epilepsy, duration of medication, and number of administrated antiepiteptic drugs.
The number of frequency of seizure before drug withdrawal was correlated with the number of frequency of withdrawal seizure. The number of seizure frequency after carbamazepine withdrawal was significantly higher during the phase of subtherapeutic or zero drug level, and not during phase of rapid falling antiepileptic drug level.
Alternative Title
Changes in Frequency of Seizure after Acute Antiepileptic Drugs Withdrawal
Keimyung Author(s)(Kor)
임정근
이상도
박영춘
Publisher
School of Medicine
Citation
김성수 et al. (1997). 항경련제 중단 후 발작의 빈도 변화. 대한신경과학회지, 15(3), 555–562.
Type
Article
ISSN
1225-7044
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39048
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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