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파킨슨병에서의 전정기능 이상

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Author(s)
이형김태완김지언이성룡오희종임정근이상도박영춘Hyung LeeTae Wan KimJi Eun KimSeong Ryong LeeHee Jong OhJeong Geun LimSang Doe YiYoung Choon Park
Keimyung Author(s)
Lee, HyungKim, Ji EunLim, Jeong GeunYi, Sang DoPark, Young ChunLee, Seong Ryong
Department
Dept. of Neurology (신경과학)
Dept. of Pharmacology (약리학)
Journal Title
대한신경과학회지
Issued Date
1998
Volume
16
Issue
2
Abstract
Background & Objectives : Qualitative oculomotor abnormalities have been reported in parkinsonian patients for many years, but conflicting results have been obtained. This study was performed to evaluate the correlation between the severity of the disease and the abnormalities of the ocular movements in idiopathic parkinson's disease. Methods : We gave the vestibular function tests in patients with idiopathic parkinson's disease and normal controls. Eye movement recordings were made with automated electronystagmography and rotation test was performed. A total of 46 patients (mean age : 61.2±6.7) and 24 controls (mean age : 60.5±4.3) were studied. The severity of the disease was divided into two groups by modified Hoehn & Yahr staging ; H-Y stage 1 and 2 as a mild group and stage 3 and 4 as a severe group. Results : Saccadic latency and accuracy, pursuitic gain and velocity, vestibulo-ocular reflex (VOR) suppression by vision were significantly altered in patients, whereas mean velocity of optokinetic nystagmus (OKN) and VOR gain in darkness were normal. Alteration of saccadic latency and accuracy, pursuitic gain and velocity, VOR suppression by vision were profound in the severe group compared with a mild group and controls, but the above parameters did not differ between a mild group and controls. In a hemiparkinson's group, saccadic latency and accuracy, pursuitic gain, OKN mean velocity and gain was not different between the both sides. Conclusion : The results indicate that severe Parkinson's disease damages nigrostriatal or other specific pathways which were involved in the regulation of the saccadic, pursuitic and pursuitic-mediated visual fixation system. In a hemiparkinson's group asymmetric damage of dopaminergic innervation which was involved in the regulation of ocular movements was not found.
Alternative Title
Vestibular Dysfunction in Patients with Idiopathic Parkinson's Disease
Keimyung Author(s)(Kor)
이형
김지언
임정근
이상도
박영춘
이성용
Publisher
School of Medicine
Citation
이형 et al. (1998). 파킨슨병에서의 전정기능 이상. 대한신경과학회지, 16(2), 172–179.
Type
Article
ISSN
1225-7044
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39090
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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