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내측두엽간질 환자에서 재단식 전측두엽절제술이 사고력과 기억력에 미치는 효과

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Author(s)
권오대김지언김진석이상도O-Dae KwonJi-Eun KimJin-Suk KimSang-Doe Yi
Keimyung Author(s)
Yi, Sang Do
Department
Dept. of Neurology (신경과학)
Journal Title
대한신경과학회지
Issued Date
2001
Volume
19
Issue
2
Abstract
Background : There exist considerable debates concerning about the effects of epilepsy surgery on cognitive function. To evaluate the effects of tailored anterior temporal lobectomy with amygdalohippocampectomy (ATLAH) on intelligence and memory, we compared the pre- and post-operative cognitive function in patients with mesial temporal lobe epilepsy (MTLE). Methods : Thirty six patients who received unilateral tailored ATLAH from 1993 to 1997 and had been seizure-free for at least two years postoperatively were selected. Mean age at the time of surgery was 26.8 years and mean period of postoperative follow-up was 47 months. The change of cognitive function was assessed preand post-operatively using Korean Wechsler Adult Intelligence Scale (K-WAIS) and Rey memory test. We also assessed the correlation between the extent of hippocampal and lateral temporal cortical resection and cognitive changes respectively. Results : In total patients (N=36), there was statistically significant improvement in performance IQ (PIQ, p<0.05), full scale IQ (FIQ, p<0.05), and auditory verbal learning test (AVLT). In the right temporal lobectomy group (N=16), improvement in PIQ, FIQ, and AVLT reached to statistical significance (p<0.05). In the left temporal lobectomy group (N=20), improvement in PIQ was significant (p<0.05). In terms of the size of resection, there were tendencies that the cognitive function is more improved in patients with larger hippocampal resection (>2 cm) and in patients with smaller temporal cortical resection (4 cm). Conclusions : Patients became seizure free after tailored ATLAH may have improvement in performance IQ and full scale IQ. Right side resection, larger hippocampal resection, and smaller lateral temporal resection show better postoperative cognitive function.
Alternative Title
Effects of Tailored Anterior Temporal Lobectomy on Intelligence and Memory Function in Patients with Mesial Temporal Lobe Epilepsy
Keimyung Author(s)(Kor)
이상도
Publisher
School of Medicine
Citation
권오대 et al. (2001). 내측두엽간질 환자에서 재단식 전측두엽절제술이 사고력과 기억력에 미치는 효과. 대한신경과학회지, 19(2), 116–124.
Type
Article
ISSN
1225-7044
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39164
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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