계명대학교 의학도서관 Repository

일과성 전뇌허혈 후 뇌조직내 Polyamine 함량 변동과 신경세포 손상에 대한 Ibuprofen의 효과

Metadata Downloads
Author(s)
이승환이성룡임정근이형이상도Seung-Hwan LeeSeong-Ryong LeeJeong-Geun LimHyung LeeSang-Doe Yi
Keimyung Author(s)
Lim, Jeong GeunLee, HyungYi, Sang DoLee, Seong Ryong
Department
Dept. of Neurology (신경과학)
Dept. of Pharmacology (약리학)
Journal Title
대한신경과학회지
Issued Date
2002
Volume
20
Issue
3
Abstract
Background : In brain ischemia, increased arachidonic acid metabolism can play important roles in neuronal damage. Ibuprofen was reported to have a protective role against neuronal damage in focal brain ischemia and reperfusion. The present study was designed to investigate whether ibuprofen can inhibit the global ischemia-induced neuronal damage and changes of polyamine (PA) level which is known to related to the neuronal damage, breakdown of blood brain barrier, and brain edema. Methods : Male Mongolian gerbils were used in this study. Transient global ischemia was induced by occlusion of bilateral common carotid arteries for 3 min with microclips. Ibuprofen was administered immediately after ischemia. The animals were sacrificed one day after ischemia for PA measurement and sacrificed 5 days after ischemia for histological evaluation. Histological examination was performed by counting surviving neuronal cells in one mm of CA1 area in dorsal hippocampus. Results : Cerebral cortex and hippocampal putrescine(PU) levels in vehicle-treated ischemic group significantly increased comparing to sham-operated animals and the increase of PU was attenuated by ibuprofen administration (50 mg/kg). Hippocampal spermine level decreased significantly after ischemia. Hippocampal neuronal cell damage in CA1 area was markedly observed in vehicle-treated animals compared to sham operated animals. Ibuprofen administration at the dose of 50 mg/kg significantly inhibited hippocampal CA1 neuronal damage compared to vehicle-treated animals. Conclusions : Ibuprofen attenuates PA response following transient global ischemia and may have putative neuroprotective effect against neuronal damage induced by global ischemia.
Alternative Title
Effect of Ibuprofen on the Changes of Polyamine Level and Neuronal Cell Damage after Transient Global Ischemia in Gerbil
Keimyung Author(s)(Kor)
임정근
이형
이상도
이성용
Publisher
School of Medicine
Citation
이승환 et al. (2002). 일과성 전뇌허혈 후 뇌조직내 Polyamine 함량 변동과 신경세포 손상에 대한 Ibuprofen의 효과. 대한신경과학회지, 20(3), 265–272.
Type
Article
ISSN
1225-7044
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39193
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.