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말단비대증의 경접형동 미세수술 결과

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Author(s)
김일만임만빈이창영Il-Man KimMan-Bin YimChang-Young Lee
Keimyung Author(s)
Kim, ElYim, Man BinLee, Chang Young
Department
Dept. of Neurosurgery (신경외과학)
Journal Title
대한신경외과학회지
Issued Date
2002
Volume
32
Issue
8
Abstract
Objective:The authors present a retrospective clinical analysis of transsphenoidal surgery for acromegaly including preoperative factors determining the therapeutic outcome.
Methods:Forty-three patients(24 females, mean age 45.3 years) harboring growth hormone(GH)-secreting adenomas(13 microadenomas and 30 macroadenomas) were treated between the years 1987 and 2001. The mean duration of follow-up was 69 months.
Results:The average estimated duration of symptoms prior to diagnosis was 8 years. The control rate following surgery was 51%(22 out of 43 cases). Of the patients with postoperative persistent disease, 11 patients had had additional bromocriptine therapy with or without irradiation, and consequently 7 patients achieved biochemical remission. The overall remission rate of multimodality treatment was 67%. The preoperative GH value, tumor size, extrasellar extension of tumor, the number of surgeons, and the extent of the surgical removal were significant univariative predictors of outcome(p<0.05).
Conclusion:This study suggests that surgical outcome for acromegaly could be achieved by a experienced neurosurgeon. In the group of the patients of large or invasive adenomas, with the less probability of surgical control, adjunctive medical or radiation therapy to control GH hypersecretion should be considered.
Alternative Title
The Outcome of Transsphenoidal Microsurgery for Acromegaly
Keimyung Author(s)(Kor)
김엘
임만빈
이창영
Publisher
School of Medicine
Citation
김일만 et al. (2002). 말단비대증의 경접형동 미세수술 결과. 대한신경외과학회지, 32(8), 131–135.
Type
Article
ISSN
1225-8245
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39197
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
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