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돼지를 이용한 표준화된 화상 모델의 구현

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Author(s)
박성철손대구박관규한기환Sungchul ParkDaegu SonKwangyu ParkKihwan Han
Keimyung Author(s)
Son, Dae GuHan, Ki HwanPark, Kwan Kyu
Department
Dept. of Plastic Surgery (성형외과학)
Dept. of Pathology (병리학)
Journal Title
대한성형외과학회지
Issued Date
2004
Volume
31
Issue
5
Abstract
A standardized animal model with an identical burn wound depth is necessary to carry out a study on burn wound healing. It should be easy to operate, reliable and reproducible. The authors used pigs because they histologically resembles human skin most. The method of getting the pigs burned embodied a standardized burn models by using a digitally controlled aluminum thermal block designed by the authors. Nine pigs were burned by maintaining the heat at 70℃ for 10 seconds, 15 seconds and 20 seconds, respectively, and at 80℃, 85℃, 90℃, 95℃ and 100℃, every 5 seconds, 10 seconds and 15 seconds, for a total of 54 contact burn wounds. And another six pigs were burned at same contact time and temperature (n=3). Another three pigs were burned by maintaining the heat at 80℃ for 10 seconds to produce 30 more contact burn wounds (n=30). After wounding, the burned skin was biopsied, stained with H&E and observed under microscopy. Two pathologists measured the vertical distance between the basement membrane and dermal tissue of the deepest burned tissue. The depth of burn increased at a regular phase in proportion to the temperature and the time of increasing temperature. The depth of 30 biopsies of the burned tissue at 80℃ for 10 seconds was similar statistically. Therefore, the standardized burn model of a pig, made by using digitally controlled aluminum thermal block is highly simple, reliable and reproducible for a standardized burn model, and will be very helpful in the study of burn wound healing.
Alternative Title
A Standardized Model of Partial Thickness Burn in Domestic Pig
Keimyung Author(s)(Kor)
손대구
한기환
박관규
Publisher
School of Medicine
Citation
박성철 et al. (2004). 돼지를 이용한 표준화된 화상 모델의 구현. 대한성형외과학회지, 31(5), 707–713.
Type
Article
ISSN
1015-6402
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39218
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
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