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항간질약물의 복용이 간질 환자의 골밀도 및 골대사에 미치는 영향

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Author(s)
박상원조용원허재훈신용억이현아이준이형임정근이상도Sang-Won ParkYong-Won ChoJae-Hun HerYong-Euk ShinHyun-Ah YiJun LeeHyung LeeJeong-Geun LimSang-Doe Yi
Keimyung Author(s)
Cho, Yong WonYi, Hyon AhLee, JunLee, HyungLim, Jeong GeunYi, Sang Do
Department
Dept. of Neurology (신경과학)
Journal Title
대한신경과학회지
Issued Date
2004
Volume
22
Issue
4
Abstract
Background: Bone mineral density (BMD) is influenced by genetic, hormonal, and environmental factors. Long-term antiepileptic drug (AED) use also causes osteopenia or osteoporosis that have been most extensively described in institutionalized patients. But, the mechanism of these abnormalities is unclear. The objective of this study is to determine the effect of AED on bone density and to explain the pathophysiologic mechanisms by analyzing bone related factors. Methods: We prospectively examined BMD by dual-energy X-ray absorptiometry in 45 patients with epilepsy. We measured the serum calcium, phosphorus, protein, alkaline phosphatase (ALP), bone specific ALP, vitamin D and osteocalcin to analyze the factors that influence bone metabolism. Results: BMD was significantly lower in the patient group than in the control group (p<0.05). 13% of patients had osteopenia and 3% of patients had osteoporosis. The level of bone specific ALP was higher in the patient group, but the level of vitamin D was not different, implying that BMD is decreased by the direct effect of antiepileptic drugs. There was a weak negative correlation and marginal significance between BMD and the duration of therapy in the patient group (r=-0.407, p<0.05). Conclusions: Long-term antiepileptic drug therapy in patients who have seizures causes significant bone loss in the lumbar spine even in the absence of vitamin D deficiency. In addition, the degree of bone mineral density was weakly related with the therapeutic duration of antiepileptic drugs. The regular evaluation of BMD in patients with long-term antiepileptic drugs might be helpful to prevent decreases in BMD.
Alternative Title
Effect of Antiepileptic Drugs on Bone Mineral Density and Bone Metabolism in Epileptic Patients
Keimyung Author(s)(Kor)
조용원
이현아
이준
이형
임정근
이상도
Publisher
School of Medicine
Citation
박상원 et al. (2004). 항간질약물의 복용이 간질 환자의 골밀도 및 골대사에 미치는 영향. 대한신경과학회지, 22(4), 310–314.
Type
Article
ISSN
1225-7044
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39237
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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