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Tacrolimus 연고제로 호전을 보인 항문 주위 크론병 3례

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Author(s)
박문호최원정황진복Moon Ho ParkWon Joung ChoiJin-Bok Hwang
Keimyung Author(s)
Hwang, Jin Bok
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
대한소아소화기영양학회지
Issued Date
2005
Volume
8
Issue
1
Abstract
Crohn’s disease of the perineum is notably resistant to treatment. We describe our experiences of tacrolimus ointment application in three patients with intractable perianal Crohn’s disease. At the time of diagnosis patients showed anal fissure with ulcer, anal fistula, or perianal abscess, respectively. These lesions did not respond to steroid, metronidazole, mesalazine, or azathioprine, though the pediatric Crohn’s disease activity index was markedly improved during the treatment period (4 to 12 months). Topical tacrolimus was applied and resulted in marked healing and a rapid granulation of cavity edges within 6 weeks to 3 months. Topical tacrolimus at a low dose shows a promise for the management of childhood perianal Crohn’s disease. Further controlled studies are required to assess the efficacy and safety of this treatment.
저자들은 기존의 크론병 치료에 호전이 없었던 항문 주위 병변에 0.3 mg/g의 저농도 tacrolimus 연고제를 1일 2회 환부에 도포하는 방법으로 약물에 의한 부작용 발생 없이 병변의 현저한 호전을 보인 3례를 경험하였기에 보고하는 바이다.
Alternative Title
Topical Tacrolimus Resulting in a Marked Resolution of Perianal Crohn’s Disease
Keimyung Author(s)(Kor)
황진복
Publisher
School of Medicine
Citation
박문호 et al. (2005). Tacrolimus 연고제로 호전을 보인 항문 주위 크론병 3례. 대한소아소화기영양학회지, 8(1), 70–75.
Type
Article
ISSN
1229-0114
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39246
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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