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콘드로이틴 황산염을 결합한 I형 콜라겐지지체와 연골세포를 이용한 연골재생

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Author(s)
임중재손대구손경희양은경한기환Joong Jae LimDaegu SonKyounghee SohnEunkyung YangKihwan Han
Keimyung Author(s)
Son, Dae GuHan, Ki Hwan
Department
Dept. of Plastic Surgery (성형외과학)
Journal Title
대한성형외과학회지
Issued Date
2007
Volume
34
Issue
4
Abstract
PURPOSE: In this study, porous type I collagen scaffolds were cross-linked using dehydrothermal(DHT) treatment and/or 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide(EDC), in the presence and absence of chondroitin-6-sulfate(CS) and cultured autologous chondrocytes(Chondro) for cartilage regeneration.
METHODS: Cartilage defects were created in the proximal part of the ear of New Zealand rabbits. Four prepared types of scaffolds(n=4) were inserted. The groups included Chondro-Collagen-DHT(Group 1), Chondro- Collagen-DHT-EDC(Group 2), Chondro-CS-Collagen- DHT(Group 3), and Chondro-CS-Collagen-DHT-EDC (Group 4). Histomorphometric analysis and cartilage- specific gene expression of the reconstructed tissues were evaluated 4, 8, and 12 weeks after implantation.
RESULTS: EDC cross-linked groups 2 and 4 regenerated more cartilage than other groups. However, calcification was observed in the 4th week after implantation. CS did not increase chondrogenesis in all groups. Cartilage-specific type II collagen mRNA expression increased in the course of time in all groups.
CONCLUSION: EDC cross-linking methods maintain the scaffold and promote extracellular matrix production of chondrocytes.
Alternative Title
Effect of cultured chondrocyte-seeded chondroitin-sulfate conjugated type I collagen scaffold on cartilage regeneration
Keimyung Author(s)(Kor)
손대구
한기환
Publisher
School of Medicine
Citation
임중재 et al. (2007). 콘드로이틴 황산염을 결합한 I형 콜라겐지지체와 연골세포를 이용한 연골재생. 대한성형외과학회지, 34(4), 413–419.
Type
Article
ISSN
1015-6402
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39294
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
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