계명대학교 의학도서관 Repository

Expression of Cancer-Testis Genes in Brain Tumors

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Author(s)
Myoung-Hee LeeEun-Ik SonEalmaan KimIn-Soo KimMan-Bin YimSang-Pyo Kim
Keimyung Author(s)
Son, Eun IkKim, ElKim, In SooYim, Man BinKim, Sang Pyo
Department
Dept. of Neurosurgery (신경외과학)
Dept. of Pathology (병리학)
Journal Title
대한신경외과학회지
Issued Date
2008
Volume
43
Issue
4
Abstract
Objective : Cancer-testis (CT) genes are considered promising candidates for immunotherapeutic approaches. The aim of this study was to investigate which CT genes should be targeted in immunotherapy for brain tumors.
Methods : We investigated the expression of 6 CT genes (MAGE-E1, SOX-6, SCP-1, SSX-2, SSX-4, and HOMTES-85) using reverse-transcription polymerase chain reaction in 26 meningiomas and 32 other various brain tumor specimens, obtained from the patients during tumor surgery from 2000 to 2005.
Results : The most frequently expressed CT genes of meningiomas were MAGE-E1, which were found in 22/26 (85%) meningioma samples, followed by SOX-6 (9/26 or 35%). Glioblastomas were most frequently expressed SOX-6 (6/7 or 86%), MAGE-E1 (5/7 or 71%), followed by SSX-2 (2/7 or 29%) and SCP-1 (1/7 or 14%). However, 4 astrocytomas, 3 anaplastic astrocytomas, and 3 oligodendroglial tumors only expressed MAGE-E1 and SOX-6. Schwannomas also expressed SOX-6 (5/6 or 83%), MAGE-E1 (4/6 or 67%), and SCP-1 (2/6 or 33%).
Conclusion : The data presented here suggest that MAGE-E1 and SOX-6 genes are expressed in a high percentage of human central nervous system tumors, which implies the CT genes could be the potential targets of immunotherapy for human central nervous system tumors.
Keimyung Author(s)(Kor)
손은익
김엘
김인수
임만빈
김상표
Publisher
School of Medicine
Citation
Myoung-Hee Lee et al. (2008). Expression of Cancer-Testis Genes in Brain Tumors. 대한신경외과학회지, 43(4), 190–193. doi: 10.3340/jkns.2008.43.4.190
Type
Article
ISSN
1225-8245
DOI
10.3340/jkns.2008.43.4.190
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39325
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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