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Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome

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Author(s)
Joon Cheol ParkSu Yeon LimTae Kyu JangJin Gon BaeJong In KimJeong Ho Rhee
Keimyung Author(s)
Park, Joon CheolBae, Jin GonKim, Jong InRhee, Jeong Ho
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
Clinical and Experimental Reproductive Medicine
Issued Date
2011
Volume
38
Issue
1
Abstract
Objective: This study was aimed to investigate endometrial histology and to find predictable clinical factors for endometrial disease (hyperplasia or cancer) in women with polycystic ovary syndrome (PCOS).
Methods: We investigated the endometrial histology and analyzed the relationship between endometrial histology and clinical parameters, such as LH, FSH, estradiol, testosterone, fasting and 2 hours postprandial glucose and insulin, insulin resistance, body mass index, endometrial thickness, menstrual status from 117 women with PCOS. Statistical analysis was performed with chi square and t-test, p-value < 0.05 was considered as statistically significant. And receiver operating characteristic curve was used to find predictable clinical factors for endometrial disease and to decide the cuff off values.
Results: In 117 women with PCOS, endometrial histologic profiles are as follows: proliferative phase in 90 women (76.9%), endometrial hyperplasia in 25 women (21.4%), and endometrial cancer in 2 women (1.7%). Of 25 women with endometrial hyperplasia, simple hyperplasia without atypia, complex hyperplasia without atypia and complex hyperplasia with atypia were diagnosed in 15 (12.8%), 6 (5.1%), 4 (3.4%) women, respectively. Age and endometrial thickness were significantly related with endometrial disease, p= 0.013 and p= 0.001, respectively. At the cut off level of 25.5 years in age, sensitivity and specificity predicting for endometrial disease were 70.4% and 55.6%, respectively (p= 0.023). At the cut off level of 8.5 mm in endometrial thickness, sensitivity and specificity were 77.8% and 56.7%, respectively (p= 0.000).
Conclusion: In women with PCOS, the incidence of endometrial hyperplasia and cancer were 21.4% and 1.7%. The age and endometrial thickness may be used as clinical determining factors for endometrial biopsy.
Keimyung Author(s)(Kor)
박준철
배진곤
김종인
이정호
Publisher
School of Medicine
Citation
Joon Cheol Park et al. (2011). Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome. Clinical and Experimental Reproductive Medicine, 38(1), 42–46. doi: 10.5653/cerm.2011.38.1.42
Type
Article
ISSN
2233-8233
DOI
10.5653/cerm.2011.38.1.42
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39357
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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