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Clinical Courses of Primary Hepatic Angiosarcoma: Retrospective Analysis of Eight Cases

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Author(s)
정우진Chang Jae HurBo Ram MinYoo Jin LeeByung Kuk JangJae Seok HwangEun Soo KimKyung Sik ParkKwang Bum ChoYu Na KangWoo Jin Chung허창재민보람이유진장병국황재석김은수박경식조광범강유나
Keimyung Author(s)
Lee, Yoo JinJang, Byoung KukHwang, Jae SeokKim, Eun SooPark, Kyung SikCho, Kwang BumChung, Woo JinKang, Yu Na
Department
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Journal Title
Korean Journal of Gastroenterology
Issued Date
2015
Volume
65
Issue
4
Abstract
Background/Aims: Hepatic angiosarcoma, a rare and aggressive liver malignancy, is difficult to diagnose because of a lack of specific clinical features. The clinical and radiological features of patients with histologically confirmed hepatic angiosarcoma were examined.
Methods: Among 2,336 patients diagnosed with primary hepatic carcinoma at Keimyung University Dongsan Medical Center(Daegu, Korea) between May 2002 and February 2012, eight (0.03%) with histologically confirmed primary hepatic angiosarcoma were included. The patterns of disease diagnosis, tumor characteristics, treatment responses, and prognoses were reviewed retrospectively.
Results: Median age was 66 years-old (range, 41-80 years). Four patients were male. Five patients were compulsive drinkers. All patients had no HBsAg and anti-HCV. Initial radiologic diagnoses revealed primary hepatic angiosarcoma (n=2), hepatocellular carcinoma (n=2), hemangioma (n=2), and hepatic metastatic carcinoma (n=2). Definitive diagnoses were made by percutaneous needle biopsies in seven patients and surgical resection in one patient. At the time of the initial diagnosis, extrahepatic metastases were detected in three patients (37.5%). Metastatic sites included the spleen and lung, pericardium, and bone, in one patient each. Two patients underwent conservative treatments. The remaining patients underwent surgical resection (n=1), transcatheter arterial chemoembolization (n=1), and systemic chemotherapy (n=4). The median survival period was 214 days (range, 21-431days).
Conclusions: Hepatic angiosarcoma is a highly progressive disease with a poor prognosis. Detailed studies including histological examinations are essential to facilitate early diagnosis of the disease.
Alternative Title
원발성 간혈관육종의 임상적 고찰: 8예 분석
Keimyung Author(s)(Kor)
이유진
장병국
황재석
김은수
박경식
조광범
정우진
강유나
Publisher
School of Medicine
Citation
정우진 et al. (2015). Clinical Courses of Primary Hepatic Angiosarcoma: Retrospective Analysis of Eight Cases. Korean Journal of Gastroenterology, 65(4), 229–235. doi: 10.4166/kjg.2015.65.4.229
Type
Article
ISSN
1598-9992
DOI
10.4166/kjg.2015.65.4.229
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39398
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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