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t(3;21)(q26;q22)를 동반한 Ph 양성 만성골수성백혈병의 골수성 모세포발증기 1예

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Author(s)
최귀전전효진전동석김재룡권기영
Keimyung Author(s)
Chun, Hyo JinJeon, Dong SeokKim, Jae RyongKwon, Ki Young
Department
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Internal Medicine (내과학)
Journal Title
대한임상병리학회지
Issued Date
1997
Volume
17
Issue
1
Keyword
Chronic Myeloid LeukemiaBlast Crisist(3:21)
Abstract
The t(3:21) (q26:q22) is associated with chronic myelogenous leukemia in blast crisis, leukemia evolving from therapy-related myelodysplasia, and with leukemia following other hematopoietic proliferative diseases. The t(3:21) is rare secondary aberration in blast crisis of Philadelphia(Ph)-positive chronic myeloid leukemia, which may be restricted to patients entering myeloid blast crisis. We report here in one case of chronic myeloid leukemia in blast crisis which reveals both t(9:22) (q34:q11), and t(3:21) (q26:q22). A 62-year-old male was diagnosed as chronic myeloid leukemia 5 years ago, received hydroxyurea therapy, and admitted because of gingival bleeding and fever. On examination, splenomegaly and leukocytosis with proliferated blasts(91%) in peripheral blood were noted. Bone marrow aspirate showed hypercellularity with severe blast proliferation(92.5%) which revealed all negative in peroxidase and PASstain. Cytogenetic study of bone marrow cells showed the karyotype 46, XY, t(3:21)(q26:q22), t(9:22) (q34:q11), which might be suspected as myeloid blast crisis. Above finding was confirmed by the result of immunophenotyping(CD13 43.6%. CD34 68.2%, HLA-DR 91.6%). He received intensive chemotherapy, but still sustained proliferation of blasts was noted. The follow up cytogenetic study was as follows: 46,XY, t(3:21)(q26:22), t(9:22)(q34:q11)/46, XY, t(3:21)(q26:q22), del(8)(q22), t(9:22)(q34: q11)/46,XY (16/3/1). He died soon from severe pancytopenia and sepsis.
Alternative Title
A Case of Myeloid Blast Crisis of Ph-positive Chronic Myeloid Leukemia with t(3;21)(q26;q22)
Keimyung Author(s)(Kor)
전효진
전동석
김재룡
권기영
Publisher
School of Medicine
Citation
최귀전 et al. (1997). t(3;21)(q26;q22)를 동반한 Ph 양성 만성골수성백혈병의 골수성 모세포발증기 1예. 대한임상병리학회지, 17(1), 21–27.
Type
Article
ISSN
1015-6445
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39424
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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