임신 중기 임신중절에서의 Misoprostol의 질내 투여와 Sulprostone(Nalador®)의 정맥내 투여의 비교

Abstract

To compare the efficiency, success rate and abortion time of applications of intravaginal miso­prostol versus intravenous Sulprostone(Nalador®) for mid-trimester pregnancy termination. Eighty three patients between 17 - 29 weeks of gestation with medical, obstetric, or genetic reasons for termination· of pregnancy were randomized to receive either 50 ug tablets of mi­soprostol placed in the posterior vaginal fornix or 1,000ug sulprostone intravenously diluted I L of isotonic saline solution given as a 12-h infusion. Among eighty three patients recruited, fourty five patients received misoprostol and thirty eight patients received sulprostone intravenously. The average interval from start of induction to vaginal delivery was 13.35 ± 3.34 hours in misoprostol group and 21.14±6.64 hours in the sulprostone group. The success rate of complete termination within 1􀂗 and 24 hours in misoprostol group were 57.7%, 93.3%, respectively, while in sulprostone group were 15.8%, 92.1% respectively. Oxytocin augumentation was 6.7% in misoprostol group and 7.9% in the sulprostone group. No serious complication occurred. lntravaginal misoprostol appears to be acceptably safe and effective agents for second trimester pregnancy termination. Misoprostol has the advantage of being inexpensive, easily stored and readily available. The regimen of 100 ug misoprostol inserted intracervicovaginally every 8 hours is the optimal method for pregnancy termination.