계명대학교 의학도서관 Repository

Comparison of Outcomes according to the Time of Initial Surfactant Treatment for Very Low Birth Weight Infants: A Multicenter Study

Metadata Downloads
Author(s)
Na Mi LeeJung Ju LeeChun Soo KimEun Ryoun KimJae Won ShimJae Woo LimMin Hee KimSang Kee ParkYoung Ah Lee
Keimyung Author(s)
Kim, Chun Soo
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
대한주산의학회잡지
Issued Date
2012
Volume
23
Issue
2
Keyword
Pulmonary surfactantVery low birth weight infantsRespiratory distress syndromeNewborn폐표면활성제저출생체중아호흡곤란증후군신생
Abstract
Purpose : The prophylactic surfactant treatment has been found to improve patient outcomes, compared to the rescue treatment. We performed a multicenter study to determine the relationship between the timing of the initial surfactant treatment and patient outcomes.
Methods : One hundred and seventy one neonates, born at eight different centers, from January 1, 2004 to December 31, 2005, were enrolled. The included subjects were gestational age less than 34 weeks, birth weights less than 1500 g and had respiratory distress syndrome (RDS) that received surfactant. First, a group that received surfactant within two hours after birth was compared to a group that received surfactant after two hours. Next, a group that received surfactant within 30 minutes after birth was compared to a group that received surfactant after 30 minutes.
Results : The mean time after birth at which the initial surfactant was administered to neonates was 140.0 ± 114.3 minutes. The incidence of patent ductus arteriosus (PDA), duration of ventilatory support and hospital days were significantly reduced in the group that received surfactant within two hours after birth. The incidence of PDA and duration of ventilatory support were significantly reduced in the group that received surfactant within 30 minutes after birth.
Conclusion : Surfactant treatment should be provided to premature infants, as soon as possible.
목적 : 미숙아에서 호흡곤란증후군으로 진단 후에 치료하는 것보다 예방적으로 일찍 폐표면활성제를 투여하였을 때 환자들의 예후가 좋다는 것이 많이 보고되고 있다. 저자들은 다기관 연구를 통해 초기 폐표면활성제 투여의 시간과 그에 따른 결과를 비교 분석하였다.
방법 : 2004년 1월부터 2005년 12월까지 8개의 병원에서 태어난 출생체중 1,500 g 미만, 재태연령 34주미만의 환아들 중 호흡곤란증후군으로 진단된 환아들 171명을 대상으로 하였다. 우선 폐표면활성제 투여시간을 출생 후 2시간을 기준으로 나누어 군간 비교 분석하였고, 그 다음으로 투여시간을 출생 후 30분을 기준으로 나누어 군간 결과를 비교 분석하였다.
결과 : 환아들의 초기 폐표면활성제 투여시간은 평균 140.0±114.3분이었다. 동맥관개존증 발생률, 인공호흡기기간, 입원기간은 출생 후2시간 이내에 폐표면활성제를 투여한 군이2시간이후에 투여한 군에 비해 통계적으로 의미있게 적었다. 30분이내에 폐표면활성제를 투여한 군도 30분이후에 투여한 군에 비해 동맥관개존증 발생률과 인공호흡기간이 의미있게 감소하였다.
결론 : 미숙아에서 폐표면활성제는 출생 후 가능한 빠른 시간내에 투여하는 것이 좋다.
Alternative Title
다기관 연구를 통한 극소저체중출생아에서 초기 폐표면활성제 투여의 시간에 따른 결과 비교
Keimyung Author(s)(Kor)
김천수
Publisher
School of Medicine
Citation
Na Mi Lee et al. (2012). Comparison of Outcomes according to the Time of Initial Surfactant Treatment for Very Low Birth Weight Infants: A Multicenter Study. 대한주산의학회잡지, 23(2), 61–68.
Type
Article
ISSN
1229-2605
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39570
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.