정상임신 및 중증전자간증에서 혈장 Antithrombin Ⅲ의 변동

Abstract

Antithrombin Ⅲ is the major in vivo serine protease inhibitor and a sensitive indicator of excess clotting activity. Some author reported that the level of plasma antithrombin Ⅲ level is unaltered during normal pregnancy and primigravida women with preeclampsia had both a significant and potential pathologic decline in antithrombin Ⅲlevel compared to either healty pregnant women or women with chronic hypertension. To investigate the alterations of antithrombin Ⅲ level in normal pregnancy and severe preeclampsia and investigate the efficiency of antithrombin Ⅲ level in diagnosis and treatment of severe preeclampsia, plasma was sampled from 254 normal pregnancy women without pregnancy complications and hyperteneive condition until 72 hours after delivery and 46 severe preeclampstic women as study group and 35 nonpregnant healthy women were as control group. There was statistically significant difference between normal pregnancy and severe preeclampsia in antithrombin Ⅲ level (P <0.0001). The normal cutoff value of antithrombin Ⅲ was 21 mg/dl by ROC curve. The specifitity, sensitivity, positive predictive value, negative predictive value, efficiency of antithrombin Ⅲ in diagnosis of severe preeclampsia showed 93 %, 78.3 %, 67.9 %, 96.0 %, 90.1 %. Antithrombin Ill suggest a relatively good test for diagnosis of severe preeclampsia.