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HaCaT 각질형성세포 및 섬유아세포에서 말기름의 항세균, 염증성 사이토카인 및 제 1형 교원질 발현에 대한 영향

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Author(s)
최경화이영선윤지현유왕근김미려이규석조재위
Keimyung Author(s)
Lee, Kyu SukCho, Jae We
Department
Dept. of Dermatology (피부과학)
Journal Title
대한피부과학회지
Issued Date
2014
Volume
52
Issue
1
Keyword
Anti-bactericidal effectHorse oilIL-10Type I collagen
Abstract
Background: Anti-inflammation, anti-bactericidal, and collagen synthesis are important for health skin conditions. However, the effect of horse oil on anti-inflammation, anti-bactericidal, and collagen synthesis is largely unknown.
Objective: The aim of this study was to evaluate the anti-bactericidal, anti-inflammatory, and synthesis of type I collagen of horse oil. Methods: Anti-bacterial effect was evaluated by disc diffusion test. Expressions of inflammatory cytokines were studied by RT-PCR analysis, real time PCR. Type I collagen expression was evaluated by Western blot in human HaCaT kertinocytes and fibroblasts. Results: Our data showed that horse oil exerted anti-bacterial effect on P.acnes and S.aureus. Expression of IL-10 was increased by horse oil-treated HaCaT cells. In addition, increased expression of type I collagen was observed in horse oil-treated human skin fibroblasts.
Conclusion: Horse oil exerts an anti-bactericidal effect against P.acnes and S.aureus. In addition, anti-inflammatory and anti-aging effects of horse oil will be mediated by up-regulation of IL-10 and type I collagen, respectively.
Alternative Title
Effect of Horse Oil on Anti-bacterial, Inflammatory Cytokines, and Type I Collagen
Expressions in Human HaCaT Keratinocytes and Fibroblasts
Keimyung Author(s)(Kor)
이규석
조재위
Publisher
School of Medicine
Citation
최경화 et al. (2014). HaCaT 각질형성세포 및 섬유아세포에서 말기름의 항세균, 염증성
사이토카인 및 제 1형 교원질 발현에 대한 영향. 대한피부과학회지, 52(1), 1–6.
Type
Article
ISSN
0494-4739
Source
http://kiss.kstudy.com/thesis/thesis-view.asp?key=3200753
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39768
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
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