Thiazide 복용 중인 고혈압 환자에서 발생한 Allopurinol 과민증후군 2예

Abstract

Allopurinol hypersensitivity syndrome (AHS) is a tate immunologic reponse to allopurinol, cha-racterized by multiple findings such as skin rash, fever, hepatic dysfunction, decreased renal function, leukocytosis and eosinophilia. The risk developing AHS tend to increase in patients receiving thiazide therapy or in those who have a pre-existing renal disease. We report two cases of AHS in patients who were taking thiazide medication due to hypertension and underlying renal disease. They developed an erythematous skin rash, fever, renal dyfunction, and eosinophilia after allopurionol therapy.