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나종형나 및 나성결절홍반 환자에서의 뇨중 Neopterin치의 변동

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Author(s)
김병천이규석송준영곽춘식
Keimyung Author(s)
Kim, Byung ChunLee, Kyu SukSong, Joon YoungKwak, Chun Sik
Department
Dept. of Dermatology (피부과학)
Dept. of Biochemistry (생화학)
Journal Title
대한피부과학회지
Issued Date
1988
Volume
26
Issue
3
Keyword
Urinary neopterinLepromatous leprosyErythema nodosum leprosum
Abstract
In lepromatous leprosy, it is generally believed that there is not only defective CMl specific for M. leprae, but also generalized impairment of CMI and in erythema nodosum leprosum, an immune complex-mediated pathogenesis as well cell mediated immune pathogenesis have been proposed. Neopterin is a pyrazinopyrirnidine compound derived from GTP, its raised excretion has been related to activation of T-lymphocyte/macrophage axis. A study was performed to evaluate generalized CMI status in the LL and ENL and to investigate a relationship between levels of urinary neopterin and disease activity. Urinary neopterin was measured by high pressure liquid chromatography in 25 healthy subjects, in 25 patients with LL and in 25 patients with ENL. The results were as follaws 1. Urinary Neopterin levels of patients with LL was 188.9+147.3umol/mol creatinine, which was higher than that of control group(144.8+40.4umol/mol creatinine)(p<0.01). 2. Urinary Neopterin levels of patients with ENL was 884.1+970.5umol/mol creatinine, which was higher than of control group, and patients with LL(p<0.01, p<0.01). 3. Serial measurement of urinary neopterin from 1 week to 13 weeks after treatment of ENL in 4 cases of ENL showed good correlation between urinary neopterin levels and disease activity. In summary, it thus appears that measurement of urine neopterin in leprosy provides generalized CMI status and reliable index for activity of disease.
Alternative Title
Levels of Urinary Neopterin in Patients with Lepromatous Leprosy and Patients with Erythema Nodosum Leprosum
Keimyung Author(s)(Kor)
김병천
이규석
송준영
곽춘식
Publisher
School of Medicine
Citation
김병천 et al. (1988). 나종형나 및 나성결절홍반 환자에서의 뇨중 Neopterin치의 변동. 대한피부과학회지, 26(3), 306–313.
Type
Article
ISSN
0494-4739
Source
http://kiss.kstudy.com/thesis/thesis-view.asp?key=1870017
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39800
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
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