전신 광화학요법으로 치료받는 환자들에 대한 피부과 및 안과 검진 결과

Abstract

Background: Systemic PUVA therapy is a widely used method for treatment of vitiligo and psoriasis. However, there have been few studies concerning complications of systemic PUVA therapy. Objective: We examined the dermatological and ophthalmologic manifestations in-patients receiving PUVA therapy. Method: We studied 42 patients who received systemic PUVA therapy for more than six months in our department. Results the results are summarized as follows l. Among the 42 patients, the number of male and female patients were 18 (42.9%) and 24 (57.1%) respectively. The mean age at the start of PUVA was 42 years and mean cumulative UVA dace was 996 J/cm². 2. Among the 42 patients, hyperpigmentation found in 9 (21.4%), PUVA lento in 8 (19.0%), prorates in 5 (11.9%) and burn in 3 (7.1%). 3. The ophthalmologic manifestations were conjunctivitis (13 cases, 31.0%), pteygium (7 cases, 16.7%), pingueculum (6 cases, 14.3%) and cataract (3 cases, 7.1%). Conclusion. Long term exposure to PUVA causes chronic clinical side effects of PUVA. Therefore careful follow-up of patients who receive long term PUVA therapy is necessary.