전신성 홍반성 루푸스와 동반된 우췌양 표피 이형성증 1예

Abstract

Epidermodysplasia verruciformis(EV) is a rare, sometimes familial disorder characterized by chronic infection with EV-specific HPV types. It manifests itself as numerous flat warts, red and brownish macules, and pityrias:s versicolor-like lesions. Immunodeficient staies such as AIDS renal transplantation, Hodgkins dis ase, and systemic lupus erythematosus, have been associated with EV. We report a case of a 42-year old female with EV, with lesions on the chest, shoulders, and back, For about the past 2 years, she had been treated with prednisolone for systemic lupus erythematosus. Histopathological findings revealed loose basket-weave-like hyperkeratosis and there were clear large cells arranged in nests in the granular and spinous layers. Their nuclei were shrunken and pyknotic, and the clear cytoplasm was dotted with dispersed keratohyaline granules of different sizes anr shapes. Electron microscopic findings showed aggregates of many viral particles in the nuclei of displastic epidermal keratinocytes. Pan papilloma virus monoclonal Antibody positive nuclei were;hown by immunoperoxidase staining. She has been treated with CO₂laser and Tretinoin(0.1%) oin ment. The patient is being monitored for any signs of recurrence for a period of 5months