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한국인 대상포진 환자에서 Interleukin-10 촉진자 유전자의 단일염기서열변이의 특징

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Author(s)
박수정조재위이규석
Keimyung Author(s)
Cho, Jae WeLee, Kyu Suk
Department
Dept. of Dermatology (피부과학)
Journal Title
대한피부과학회지
Issued Date
2006
Volume
44
Issue
11
Keyword
Herpes zosterInterleukin-10 single nucleotide polymorphismsKoreans
Abstract
Background: Herpes zoster is a common viral infectious disease that is caused by the varicellar zoster virus (VZV).
It has been suggested that impaired cellular immunity is responsible for the reactivation of the virus, but the pathogenesis
of viral reactivation is not fully understood yet. Previous research has shown that interleukin (IL)-10 promoter
gene polymorphisms influenced the susceptibility of herpes zoster in Europeans (Finnish patients). The wide ethnical differences
of polymorphisms of the IL-10 promoter gene are known to exist between European and Asian populations, but
it has not yet been confirmed whether IL-10 polymorphisms are susceptible to herpes zoster in Koreans.
Objective: The aim of this study was to determine whether some type of polymorphisms in Koreans also influence
the susceptibility of developing herpes zoster and, if they exist, to compare the ethnic differences of polymorphisms
to those in Europeans.
Methods: The three most investigated single nucleotide polymorphisms (SNPs) situated at positions -1082 (G/A),
-819 (T/C) and -592 (C/A) 5' of the transcription start site and three haplotypes (GCC, ACC and ATA) of these
SNPs were analyzed in 74 herpes zoster patients and 216 normal controls.
Results: We found that the -1082 G allele was significantly higher in herpes zoster patients (odds ratio, 2.16; 95%
confidence interval, 1.15∼4.07; p=0.02) and the GCC haplotype was associated with development of herpes zoster in
Koreans (odd ratio, 2.34; 95% confidence interval, 1.23∼4.45; p=0.01), compared to the ATA haplotype in Finns.
Conclusion: Our results suggest that susceptibility genes do influence the development of herpes zoster in Koreans
and that ethnic differences do exist between Koreans and Europeans (Finns).
Alternative Title
Single Nucleotide Polymorphisms of Interleukin-10 Promoter Gene
in Korean Herpes Zoster Patients
Keimyung Author(s)(Kor)
조재위
이규석
Publisher
School of Medicine
Citation
박수정 et al. (2006). 한국인 대상포진 환자에서 Interleukin-10 촉진자 유전자의 단일염기서열변이의 특징. 대한피부과학회지, 44(11), 1325–1331.
Type
Article
ISSN
0494-4739
Source
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2578221
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39891
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
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