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황금추출물의 추출 방법에 따른 세포 독성 평가 및 피부 안전성 평가

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Author(s)
김형미임윤영조수묵김민영손인평석장미박진오박종호조재위김범준
Keimyung Author(s)
Cho, Jae We
Department
Dept. of Dermatology (피부과학)
Journal Title
대한피부과학회지
Issued Date
2012
Volume
50
Issue
11
Keyword
Melanin synthesisPrimary dermal irritation testScutellaria baicalensis GeorgiSkin safety test
Abstract
Background: Scutellaria baicalensis Georgi extract is used as a traditional herbal medicine. The efficacy of
Scutellaria baicalensis Georgi extract is known for antioxidative activity, antiinflammation effect, antibacterial effect,
inhibitory effect of melanin synthesis, sun protection effect, antiallergy effect, and etc.
Objective: We confirmed the cell viability or inhibitory effect of melanin synthesis in HaCaT (human keratinocyte
cell line) and B16F10 (murine melanoma cell line) cells and the skin safety test through a clinical test (dermal
irritation study) for Scutellaria baicalensis Georgi extract, according to the extraction methods.
Methods: We checked the cell viability, using MTT assay and inhibitory effect of melanin synthesis in B16F10
cells or HaCaT cells for thirty one Scutellaria baicalensis Georgi extract, according to the extraction methods. Then,
we evaluated the skin safety for selected eight Scutellaria baicalensis Georgi extract through a primary dermal
irritation test.
Results: Among the thirty one Scutellaria baicalensis Georgi extracts, according to the extraction methods, we
selected eight Scutellaria baicalensis Georgi extracts that were not detected with cell toxicity in HaCaT cells and
B16F10 cells, and could have inhibited the melanin synthesis in B16F10 cells. The selected eight Scutellaria
baicalensis Georgi extracts identified the skin safety through a primary dermal irritation test.
Conclusion: We expect clinical trials for whitening efficacy based on inhibitory effect of melanin synthesis and
human skin safety for Scutellaria baicalensis Georgi extracts.
Alternative Title
The Evaluation of Skin Safety and Skin Cell Toxicity for
Scutellaria baicalensis Georgi Extract according to Extraction Conditions
Keimyung Author(s)(Kor)
조재위
Publisher
School of Medicine
Citation
김형미 et al. (2012). 황금추출물의 추출 방법에 따른 세포 독성 평가 및 피부 안전성 평가. 대한피부과학회지, 50(11), 959–968.
Type
Article
ISSN
0494-4739
Source
http://kiss.kstudy.com/thesis/thesis-view.asp?key=3125578
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39893
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
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