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제7형 교원질 유전자의 발현에 대한 TGF-β와 TNF-α의 효과

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Author(s)
김병천류영욱이규석
Keimyung Author(s)
Kim, Byung ChunRyoo, Young WookLee, Kyu Suk
Department
Dept. of Dermatology (피부과학)
Journal Title
대한피부연구학회지
Issued Date
1996
Volume
3
Issue
2
Keyword
Type Ⅶ collagen gene expressionTGF-βTNF-αCultured keratinocytes and fibroblasts
Abstract
Type Ⅶ collagen is the predominant component of the anchoring fibrils and both dermal fibroblasts and epidermal keratinocytes in culture synthesize type Ⅶ collagen. The presence of anchoring fibrils is apparently critical for the stability of the cutaneous basement membrane zone, because abnormalities in quantity of quality of anchoring fibrils manifest as dystrophic forms of epidermolysis bullosa(EB). But there is little known about effects of cytokines on type Ⅶ collagen gene expression. We have examined the response of the fibroblasts and keratinocytes in type Ⅶ collagen gene expression to transforming growth factor-β (TGF-β) as well as tumor necrosis factor-α (TNF-α), which have been shown to modulate the expression of the extracellular matrix genes using Northern blot hybridizations ···
Alternative Title
Influence of TGF-β and TNF-α Type Ⅶ Collagen Gene Expression by Human Keratinocytes and Fibroblasts in Culture
Keimyung Author(s)(Kor)
김병천
류영욱
이규석
Publisher
School of Medicine
Citation
김병천 et al. (1996). 제7형 교원질 유전자의 발현에 대한 TGF-β와 TNF-α의 효과. 대한피부연구학회지, 3(2), 131–137.
Type
Article
ISSN
1225-8180
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39902
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
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