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피부암에서 Cyclin 유전자의 발현

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Author(s)
박재홍류영욱이규석
Keimyung Author(s)
Ryoo, Young WookLee, Kyu Suk
Department
Dept. of Dermatology (피부과학)
Journal Title
대한피부연구학회지
Issued Date
2000
Volume
7
Issue
1
Keyword
Cyclin AD1 and ESCCBCC
Abstract
Cyclins are prime cell cycle regulators and are central to the control of major check point in eukaryotic cells. But, the structural change and overexpression of cyclin mRNA demonstrated to association of oncogenesis in some cancers. Cyclins were first identified in marine invertebrates on the basis of their dramatic cell cycle periodicity during meiotic division. Cyclins function by forming a complex with and activating a family of cyclin-dependent protein kinase(CDKs), at various stages in the cell cycle. They fall into three categories ; A-type, B-type, and G1cyclins(cyclins C, D1-D3, and E). In this study, we have examined expression of cyclins(A, D1 and E) messenger RNA in basal cell carcinoma and squamous cell carcinoma(SCC) tissues and SCC cell lines by semi-quantitative RT-PCR method, immunoperoxidase stain and the results were as follows: 1. Expression of cyclin A, D1 and E genes in basal cell carcinoma, squamous cell carcinoma and SCC cell line were more increased compared with normal skin tissues. 2. Expression of cyclin A, D1 mRNA in squamous cell carcinoma were more increased compared with basal cell carcinoma. 3. Expression of cyclin E mRNA was detected in two SCC tissue and not detected in BCC tissues. 4. Expression of cyclin A, D1 and E mRNA in SCC cell line remarkably increased compared with basal cell and squamous cell carcinoma tissues. 5.Immunohistochemical stain of cyclin D1 revealed the increased production of the cyclin D in SCC tissues. In conclusion, these data suggest that cyclin A, D1 and E play a role in a subset of oncogenesis of skin cancer. However, further studies including gene analysis and Southern analysis are needed to clarify the relation between cyclins, oncogenes and other factors in oncogenesis of human skin cancers.
Alternative Title
Expression of Cyclin Genes of Human Skin Cancer
Keimyung Author(s)(Kor)
류영욱
이규석
Publisher
School of Medicine
Citation
박재홍 et al. (2000). 피부암에서 Cyclin 유전자의 발현. 대한피부연구학회지, 7(1), 54–60.
Type
Article
ISSN
1225-8180
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39903
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
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