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각질가시세포종에서의 이형접합성소실과 Microsatellite의 불안정성에 대한 분석

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Author(s)
하태원한기환김대광
Keimyung Author(s)
Han, Ki HwanKim, Dae Kwang
Department
Dept. of Plastic Surgery (성형외과학)
Dept. of Medical Genetics (의학유전학)
Journal Title
대한해부학회지
Issued Date
2005
Volume
38
Issue
1
Keyword
KeratoacanthomaMicrosaellite instabilityLoss of heterozygosity각질가시세포종microsaellite 불안정성이형접합성소실
Abstract
Tumors from patients with hereditary non-polyposis colorectal cancer (HNPCC) and from a subset of patients with the related Muir-Torre syndrome exhibit a type of a genetic instability, known as microsatellite instability (MIS), which results from mutations that inactivate DNA mismatch repair genes. Keratoacanthomas resemble squamous cell carcinoma but after a period of rapid growth over a few months they involute completely.
The detection of MIS in a keratoacanthoma from a patient with Muir-Torre syndrome suggested that defective
mismatch repair genes may play a role in the pathogenesis of these neoplasmas.
In order to elucidate the significance of both MIS and loss of heterozygosity (LOH) in the pathogenesis of sporadic keratoacanthomas, the presents of MIS and LOH at 11 microsatellite markers (D2S286, D2S367, D3S1317, D5S346, D9S16, D9S171, D10S89, D10S185, D11S904, D17S261, and D17S520) were evaluated in randomly selected
sporadic keratoacanthomas. MIS and LOH were found only in 1 of 10 cases at D17S261 and D10S185, respectively.
In conclusion, the low frequency of MIS and LOH detected in this study suggests that neither MIS nor LOH appear
to be significant in the induction of sporadic keratoacanthomas.
Alternative Title
Analysis of Microsatellite Instability and Loss of Heterozygosity in Sporadic Keratoacanthoma
Keimyung Author(s)(Kor)
한기환
김대광
Publisher
School of Medicine
Citation
하태원 et al. (2005). 각질가시세포종에서의 이형접합성소실과 Microsatellite의 불안정성에 대한 분석. 대한해부학회지, 38(1), 55–61.
Type
Article
ISSN
1225-1305
Source
http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010022939659
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39923
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Medical Genetics (의학유전학)
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
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