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Hb Queens[α34(B15)Leu→Arg] 가족 1례

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Author(s)
전동석최귀전전효진김재룡이영준박성섭조한익오바 유조하토리 유키오
Keimyung Author(s)
Jeon, Dong SeokChun, Hyo JinKim, Jae Ryong
Department
Dept. of Laboratory Medicine (진단검사의학)
Journal Title
대한혈액학회지
Issued Date
1997
Volume
32
Issue
1
Keyword
Hb QueensCation-exchange chromatographyHb A1c
Abstract
A 36-year-old pregnant woman with gestational diabetes mellitus and anemia was found to have an abnormal Hb(comprising 18.7%) in the automated midget low pressure cation-exchange chromatography(DiaSTAT TM, Bio-Rad, USA) for Hb A1c assay. The abnormal Hb revealed an abnormal peak emerged slightly later than normal Hb A1 in DiaSTAT TM chromatogram, subsequently confirmed by cellulose acetate membrane electrophoresis and isoelectric focusing. This hemoglobinopathy with high isoelectric point was noted and abnormal α chain globin was prepared by chromatography. Family study was carried out and this α chain variant was also found in four other family members, and all of them had no clinical abnormalities, except well controlled diabetes. As the results from peptide mapping, amino acid analysis and sequencing, abnormal Hb of the patient was finally identified as Hb Queens[α34(B15)Leu→Arg] without clinical abnormalities.
Alternative Title
A Family Case of Hb Queens[α34(B15)Leu→Arg]
Keimyung Author(s)(Kor)
전동석
전효진
김재룡
Publisher
School of Medicine
Citation
전동석 et al. (1997). Hb Queens[α34(B15)Leu→Arg] 가족 1례. 대한혈액학회지, 32(1), 112–118.
Type
Article
ISSN
1225-0546
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39967
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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