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Waldenström's Macroglobulinemia 14례의 임상양상

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Author(s)
배성화류헌모김동완김종광손상균이규보도영록송홍석권기영박건욱이재련이경희현명수
Keimyung Author(s)
Do, Young RokSong, Hong SukKwon, Ki YoungPark, Keon Uk
Department
Dept. of Internal Medicine (내과학)
Journal Title
대한혈액학회지
Issued Date
2003
Volume
38
Issue
4
Keyword
Waldenstom's macroglobulinemiaClinical courseKorea
Abstract
Background : Waldenström's Macroglobulinemia (WM) is a low grade lymphoproliferative
disorder that produces monoclonal immunoglobulin M (IgM). Information on the clinical feature
and outcome of Korean patients with WM is scanty.
Methods : Patients with WM newly diagnosed at 5 university hospitals in Daegu and
Gyeongju from 1990 to 2002 were enrolled. Data on 14 patients were retrospectively analyzed.
Results : The median age at diagnosis was 66 years (range: 48~77) and the male/female
ratio was 6:1. All patients except one were symptomatic at presentation. Anemia was observed
in all patients and β2 microglobulin was elevated in 90% of patients. Overall response rate
was 45% in the patients treated with alkylating agent and steroid. The median survival of our
patients was 39 months (95% confidence interval : 13.7~64.3 months) and the only factor
associated with poor survival was albumin level by univariate analysis.
Conclusion : Incidence of WM was lower and the median survival of our patients was
shorter than that of Western reports. Further studies are needed to confirm prognostic factors
and risk adapted treatment guideline of Korean WM patients.
Alternative Title
Waldenström's Macroglobulinemia : Clinical Course and Outcome of 14 Cases
Keimyung Author(s)(Kor)
도영록
송홍석
권기영
박건욱
Publisher
School of Medicine
Citation
배성화 et al. (2003). Waldenström’s Macroglobulinemia 14례의 임상양상. 대한혈액학회지, 38(4), 234–239.
Type
Article
ISSN
1225-0546
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39972
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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