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미만성 거대 B 세포 림프종에서 R-CHOP의 임상적 유효성

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Author(s)
양덕환이제중김여경변정래조상희정의주김형준김종광김동환손상균이원섭도영록송홍석박준성김효철
Keimyung Author(s)
Do, Young RokSong, Hong Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
대한혈액학회지
Issued Date
2004
Volume
39
Issue
2
Keyword
CHOPRituximabB-cell lymphoma
Abstract
BACKGROUND: In combination with standard-dose CHOP (cyclophosphamide, vincristine, adriamycin, and prednisolone), the addition of rituximab produces a better clinical response in the treatment of aggressive B-cell non-Hodgkin´s lymphoma (NHL) than CHOP alone.
METHODS : Thirty-four patients with previously untreated diffuse large B-cell NHL received at least three or four cycles of rituximab 375 mg/m2 or 500 mg per dose on day 1 of each cycle in combination with CHOP chemotherapy.
RESULTS : The median age of patients were 61.5 years (range, 28-83 years). After the end of therapy, twenty-five patients (73.5%) experienced a complete response, four patients (11.8 %) had a partial response, and two patients (5.9%) were classified as having progressive disease. The median follow-up duration was 9.4 months (range, 0.2-19.5 months) and 1-year overall survival and progression free survival was 84.8+/-8.7% and 80.3+/-9.4%, respectively. Two patients (5.9%) experienced fever, myalgia, and skin eruption due to rituximab. Neutropenia of grade 3 or 4 occurred in thirty-one patients (91.2%).
CONCLUSION : The benefits of rituximab in combination with CHOP chemotherapy include high response rates and good tolerance. However, further prospective, randomized studies are needed to draw definitive conclusions.
Alternative Title
The Clinical Efficacy of R-CHOP Chemotherapy in Patients with Previously Untreated Diffuse Large B-cell Lymphoma
Keimyung Author(s)(Kor)
도영록
송홍석
Publisher
School of Medicine
Citation
양덕환 et al. (2004). 미만성 거대 B 세포 림프종에서 R-CHOP의 임상적 유효성. 대한혈액학회지, 39(2), 59–65.
Type
Article
ISSN
1225-0546
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39978
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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