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한국의 악성 림프종에 관한 통계적 관찰

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Author(s)
한지숙고윤웅민유홍김노경김동집김민철김병수김삼용김상희김준석박병채박승철박재후박희숙서창인선덕재송홍석심영학오도연이경식이규보이석이순남이승태이종화전춘해정현철조경삼조군제진춘조최일영최진혁현명수
Keimyung Author(s)
Song, Hong Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
대한혈액학회지
Issued Date
1995
Volume
30
Issue
2
Keyword
Malignant lymphomaHodgkin diseaseNon-Hodgkin lymphomaHistopathologic typePrognostic factor
Abstract
Background: The disorder classified as malignant lymphoma are increasing in
frequency in Korea and there have been numerous advances in our understanding of the
pathophysiology of these disorders and in their treatment. There are considerable
geographic and ethnic differences in the incidence, age distribution, histopathologic types
of the malignant lymphoma.
Methods: We analyzed clinical findings of malignant lymphoma patients in Korea for
5 years. Sixteen hundred and fifty-three cases of the malignant lymphoma, which were
collected from the departments of internal medicine of 23 general hospitals and
university hospitals and department of pediatrics of one university hospital throughout
Korea, were summarized and reviewed. The data collected comprised of the cases for 5
years from January 1989 to December 1993.
Results : 1) There were 142 cases of Hodgkin disease(8.6%), and 1,511 cases of non-Hodgkin
lymphoma(91.4%) with 1 : 11 ratio.
2) The most common histopathologic type of Hodgkin disease was mixed
cellularity(54.2%), and that of non-Hodgkin lymphoma was diffuse, large cell type
(50.9%), respectively.
3) Peripheral lymphadenopathy was the most common presenting symptoms at the
time of first visit to the hospital, especially in Hodgkin disease.
4) High proportion of lymphomas(43.1% of total cases: 12.6% of Hodgkin disease and
46.3% of non-Hodgkin lymphoma) involved the extranodal sites. The most common site
was gastro-intestinal system(16.7%).
5) In treatment responses, the complete remission rate was 69.1% in Hodgkin disease
and 55.0% in non-Hodgkin lymphoma, respectively, and 13.8% of Hodgkin disease and
22.0% of non-Hodgkin lymphoma were relapsed. We observed the statistically significant
difference in survival duration between Hodgkin disease and non-Hodgkin lymphoma.
6) According to multivariate analysis, age, B-symptom, stage, LDH and number of
extranodal sites were the useful prognostic factors predicting survival.
Conclusion : The characteristics of malignant lymphoma in Korea differ from those in
the western countries with respect to the frequency of histopathologic pattern. The
epidemiologic studies are necessary for the clarification of these differences.
Alternative Title
Statistical Analysis of Malignant Lymphoma in Korea
Keimyung Author(s)(Kor)
송홍석
Publisher
School of Medicine
Citation
한지숙 et al. (1995). 한국의 악성 림프종에 관한 통계적 관찰. 대한혈액학회지, 30(2), 197–214.
Type
Article
ISSN
1225-0546
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39989
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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