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특발성골수섬유증에서 Hydroxyurea 치료 중 아세포 증식과 함께 17번 단완 결손이 관찰된 1례

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Author(s)
하정숙류남희김재룡전동석
Keimyung Author(s)
Ha, Jung SookRyoo, Nam HeeKim, Jae RyongJeon, Dong Seok
Department
Dept. of Laboratory Medicine (진단검사의학)
Journal Title
대한혈액학회지
Issued Date
2004
Volume
39
Issue
1
Keyword
17p deletionHydroxyureaIdiopathic myelofibrosis
Abstract
The recently described ´17p deletion syndrome´ is a clonal hematologic disease which has characteristic dysgranulopoietic features, such as pseudo-Pelger-Huet hypogranulation and small vacuoles in neutrophils and is strongly associated with p53 mutation. The cases with 17p deletion are seen in 3~4% of myelodysplastic syndrome and acute myelogenous leukemia and about 30% of them are therapy-related. Hydroxyurea, which is considered to have relatively low leukemogenic potential, has therefore been widely used in chronic myeloproliferative disease. But the recent study has found that hydroxyurea administration is a considerable risk for later leukemic transformation and is closely associated with development of 17p deletion. We report one case of idiopathic myelofibrosis which developed 17p deletion with blast increment after hydroxyurea therapy for 3 years.
Alternative Title
Occurence of 17p Deletion with Blast Transformation in Idiopathic Myelofibrosis Treated with Hydroxyurea
Keimyung Author(s)(Kor)
하정숙
류남희
김재룡
전동석
Publisher
School of Medicine
Citation
하정숙 et al. (2004). 특발성골수섬유증에서 Hydroxyurea 치료 중 아세포 증식과 함께 17번 단완 결손이 관찰된 1례. 대한혈액학회지, 39(1), 46–50.
Type
Article
ISSN
1225-0546
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39991
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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