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반코마이신 내성 장구균 감염에 대한 quinupristin-dalfopristin 치료 경험

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Author(s)
추은주최상호조영환정선미김백남김남중김미나김양수우준희류지소
Keimyung Author(s)
Kim, Baek Nam
Department
Dept. of Internal Medicine (내과학)
Journal Title
대한화학요법학회지
Issued Date
2002
Volume
20
Issue
1
Keyword
VRE(vancomycin-resistant enterococci)quinupristin/dalfopristinVREF infection
Abstract
Vancomycin-resistant enterococci (VRE) was first recognized in 1992 in Korea. VRE infection have been increasingly reported in immunosuppressed patients over the past decade and have become one of major nosocomial pathogens. Clinicians carings for patients with VRE infections face severe constraints in the selection of treatment. Quinupristin/dalfopristin is active in vitro againt vancomycin-resistant E. faecium (VREF), with a MIC_(90) of 1.0㎍/mL. We studied the clinical efficacy and safety of this agent in the treatment of VREF infection. Patients were included if they had signs and symptoms of active infection including bacteremia, intra-abdominal infection, and wound infection. A total of 13 patients with VREF infection were enrolled. A favorable clinical response (cure or improvement) occured in 10 of 11 evaluable patients. The only adverse events related to quinupristin/dalfopristin were arthralgia and myalgia, which occurred in 2 of 13 patients. These results suggest that quinupristin/dalfopristin is effective and safe as treatment for VREF infections in critically ill patients with serious underlying conditions.
VRE 감염이 중환자에서 급속히 증가하고 있으나 이에 대한 확실한 치료제가 없어 새로운 항생제에 대한 활발한 연구가 있는데 그 중 하나가 quinupristin/dalfopristin이고, 저자들은 중증 환자들의 VRE 감염에 대해 quinupristin/dalfopristin를 투여하여 치료한 임상적 경험을 하였기에 문헌고찰과 함께 보고하는 바이다.
Alternative Title
Clinical Experience with Quinupristin-Dalfopristin Treatment for Vancomycin-Resistant Enterococcal Infection
Keimyung Author(s)(Kor)
김백남
Publisher
School of Medicine
Citation
추은주 et al. (2002). 반코마이신 내성 장구균 감염에 대한 quinupristin-dalfopristin 치료 경험. 대한화학요법학회지, 20(1), 17–24.
Type
Article
ISSN
1225-7850
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39993
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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