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일측폐이식 실험견에서 이식폐의 기능평가연구

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Author(s)
박창권박원균권건영김진모전석길이광숙유영선
Keimyung Author(s)
Park, Chang KwonLee, Kwang SookYoo, Young SunPark, Won KyunKwon, Kun YoungKim, Jin MoZeon, Seok Kil
Department
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Dept. of Medical Education (의학교육학)
Dept. of Pathology (병리학)
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Dept. of Nuclear Medicine (핵의학)
Journal Title
대한흉부외과학회지
Issued Date
1995
Volume
28
Issue
12
Keyword
Lung transplantationLung preservationPulmonary function test
Abstract
We experienced 7 cases of left single lung transplantation in 14 mongrel dogs and analyzed graft lung function by hemodynamics, blood gas analysis, chest X-ray, biopsy and perfusion lung scan. We performed right pulmonary artery cuff[PA cuff for analysis of graft lung function in 3 cases. The donor lungs were flushed with modified Euro-Collins solution[n=3 or low potassium dextran glucose solution[n=4 and preserved for 4 to 5 hours[n=4 or 24 hours[n=3 at 10o C and implanted to the dogs with similar weight . Assessment of left graft lung was done by occluding the right pulmonary artery for 10 minutes using PA cuff. Assessment for graft lung function was done immediately after an operation and after 3 days, 7days and 3 weeks postoperatively. Four dogs survived for 3days, 7days[2 cases and 3 weeks respectively. Other three dogs expired within 3 hours of reperfusion. Immediate perfusion scans of left lung in four survived dogs after reperfusion were 42.1%, 36% , 11% and 5.9% respectively, and another dog with 4.8% perfusion to left lung was dead due to left atrial thrombi after 3 hours reperfusion. In one case among three acute rejections follow-up perfusion scan was done on 3rd and 11th postoperative day and the result decreased from 36% perfusion immediate postoperatively to 21% and 15% respectively. Three expired dogs postoperatively couldn`t tolerate occlusion of right pulmonary artery with above 40 mmHg of mean pulmonary artery pressure. On the other hand, three survival dogs postoperatively tolerated occlusion of right pulmonay artery with less than 30 mmHg of mean pulmonary artery pressure. and one dog couldn`t tolerate same procedure immediate postopertively but in 2 hours reperfusion later tolerated with 29 mmHg of mean pulmonary artery pressure.In conclusion we couldn`t compare the effect of two flushing solutions but low potassium dextran glucose solution showed relatively safe preservation effect in cases with preservation of more than 20 hours. Also canine left single lung transplantation model with PA cuff indicated useful method for the assessment of graft lung function with effect of lung preservation.
Alternative Title
An Assessment of Allograft Function in Canine Single Lung Transplantation
Keimyung Author(s)(Kor)
박창권
이광숙
유영선
박원균
권건영
김진모
전석길
Publisher
School of Medicine
Citation
박창권 et al. (1995). 일측폐이식 실험견에서 이식폐의 기능평가연구. 대한흉부외과학회지, 28(12), 1096–1106.
Type
Article
ISSN
0301-2859
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/40068
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
1. School of Medicine (의과대학) > Dept. of Medical Education (의학교육학)
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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