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만성 통증관리를 위한 정맥내 Lidocaine 점적주사시 Lidocaine 혈중 농도, 제통효과 및 부작용 관찰

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Author(s)
송선옥전동석최세영Sun Ok SongDong Seok JeonSae Young Choi
Keimyung Author(s)
Jeon, Dong SeokChoi, Sae Young
Department
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Journal Title
대한마취과학회지
Issued Date
1999
Volume
37
Issue
3
Abstract
Background : Lidocaine administered intravenously (IV lidocaine) is efficacious in the treatment of thic pain. There are many differences in doses and methods of IV lidocaine therapy. We have made a ous clinical report of IV lidocaine infusion for chronic pain patients. The aims of this study were to evaluate the plasma concentration of lidocaine, and the analgesic effect and safety of our method of IV idocaine infusion. Methods : Sixteen neuropathic pain patients received IV lidocaine infusion. Lidocaine of 5 mg/kg ixed in 150 ml of normal saline was infused over 40 min at a rate with 300 ml/h for the initial 10 min, and the remaining at 200 ml/h. Blood sampling, for the analysis of plasma lidocaine concentration, pain score by numerical rating scale, blood pressure and heart rate were obtained before the infusion and at 20, 40, 60, 90 and 120 min following the start of infusion. Results : Thirteen patients (81.3%) had analgesic effects in IV lidocaine infusion. Mean plasma caine concentrations were 0, 2.0, 2.7, 2.2, 1.5, 1.1 ug/ml, and mean pain scores were 7.6, 5.6, 3.7, 3.1, 3.0, and 3.1 before the infusion and at 20, 40, 60, 90 and 120 min following the start of infusion. Plasma aine over 2 μg/ml revealed an analgesic effect, and pain scores precipitously dropped around 40 min following the start of infusion. There were no significant changes of blood pressure and heart rate. Side effects were mild in terms of sedation, dizziness, light-headedness, nausea and metallic taste. Conclusions: These results suggest that our method of IV lidocaine infusion -within therapeutic nge of lidocaine not to allow toxic plasma concentration, and with any effective analgesia, little modynamic change and minimal side effects- is a useful and a safe diagnostic and therapeutic modality for hronic neuropathic pain. (Korean J Anesthesiol 1999; 37: 459∼466)
Key Words: Pain; chronic; neuropathic. Pharmacology; lidocaine; plasma concentration; side effects.
Alternative Title
Plasma Lidocaine Level, Analgesic Effect and Side Effect during Intravenous Lidocaine Infusion for Chronic Pain Management
Keimyung Author(s)(Kor)
전동석
최세영
Publisher
School of Medicine
Citation
송선옥 et al. (1999). 만성 통증관리를 위한 정맥내 Lidocaine 점적주사시 Lidocaine 혈중 농도, 제통효과 및 부작용 관찰. 대한마취과학회지, 37(3), 459–466. doi: 10.4097/kjae.1999.37.3.459
Type
Article
ISSN
0302-5780
DOI
10.4097/kjae.1999.37.3.459
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/40091
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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