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실험견에서 간혈류 차단 및 재관류 시 소량의 Nitroglycerin 투여에 의한 간혈류와 실시간 국소 간관류 및 산소 이용률의 변화

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Author(s)
전재규정정길배정인김진모김애라장영호안윤정이용철Jae Kyu CheunJung Kil ChungJung In BaeJin Mo KimAe Ra KimYoung Ho JangYoun Jeong AnYong Cheol Lee
Keimyung Author(s)
Cheun, Jae KyuChung, Jung KilBae, Jung InKim, Jin MoKim, Ae RaJang, Young HoLee, Yong Cheol
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
대한마취과학회지
Issued Date
2003
Volume
45
Issue
2
Abstract
Background: The Pringle maneuver is traditionally used during the hepatectomy to reduce the blood loss. However, there have been no studies about local liver perfusion (LLP) and oxygen extraction ratio (ero2) following hepatic ischemia and reperfusion. In this study, the changes in hepatic blood flow (HBF),LLP, ero2 following hepatic ischemia and reperfusion were observed. And the effects of low dose nitroglycerin (NTG) were observed too.
Methods: A total of 14 mongrel dogs were divided into two groups; control group (C, n - 7), NTG administration group (N, n - 7), NTG administration was started 5 minutes before HBF occlusion. After femoral arterial and central venous catheterization, midline abdominal incision was made. Hepatic artery (HA) and portal vein (PV) were exposed to clamp and declamp. And then doppla- flowmeter probes were applied on HA and PV to measure their blood flow and a thermal diffusion microprobe was inserted in the liver parenchyme to measure LLP.
Results: The HA and PV blood flow, LLP, and ero2 were not different between two groups. However, HBF more increased compared to the baseline level in N group after reperfusion. In C group, LLP did not recover after reperfusion. The LLP in N group recovered to the baseline level after reperfusion.
Conclusions: In conclusion, it was observed that the HBF increased and LLP recovered to the baseline level after reperfusion by administration of low dose NTG. The use of low dose NTG is safe and effective for hepatectomy. (Korean J Anesthesiol 2003; 45: 251-257)
Alternative Title
The Effect of Low Dose Nitroglycerin on Hepatic Blood Flow, Real-time Local Liver Perfusion and Oxygen Extraction Ratio Following the Occlusion and Reperfusion of Hepatic Blood Flow in Experimental Dogs
Keimyung Author(s)(Kor)
전재규
정정길
배정인
김진모
김애라
장영호
이용철
Publisher
School of Medicine
Citation
전재규 et al. (2003). 실험견에서 간혈류 차단 및 재관류 시 소량의 Nitroglycerin 투여에 의한 간혈류와 실시간 국소 간관류 및 산소 이용률의 변화. 대한마취과학회지, 45(2), 251–257. doi: 10.4097/kjae.2003.45.2.251
Type
Article
ISSN
0302-5780
DOI
10.4097/kjae.2003.45.2.251
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/40111
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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