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체외순환 없는 관상동맥우회술시 고혈압 예방을 위한 Nicardipine 혹은 Nitroglycerin의 효과

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Author(s)
홍지희엄진원장영호김진모김애라전재규박원균Ji Hee HongJin Won UhmYoung Ho JangJin Mo KimAe Ra KimJae Kyu CheunWon Kyun Park
Keimyung Author(s)
Hong, Ji HeeJang, Young HoKim, Jin MoKim, Ae RaCheun, Jae KyuPark, Won Kyun
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Dept. of Medical Education (의학교육학)
Journal Title
대한마취과학회지
Issued Date
2002
Volume
42
Issue
4
Abstract
Background: Tight control of blood pressure in patients with coronary artery disease is critical, especially in the setting of long-standing hypertension and left ventricular dysfunction. With off-pump coronary artery bypass graft (CABG), hypertension usually occurs after the sternotomy, along with an increase in heart rate and filling pressure. In order to minimize hypertension during this period, nitroglycerin or nicardipine was prophylactically infused.
Methods: Twenty patients scheduled to undergo an off-pump CABG from April to August, 2001, were selected and divided into two groups. Group I (n = 10) received nicardipine and Group II (n = 10) received nitroglycerin. Before the skin incision, nicardipine (0.5-1.0μg/kg/min) or nitroglycerin (0.5-1.0μg/kg/min) was continuously infused. Mean arterial pressure (MAP), heart rate (HR), mean pulmonary artery pressure (mPAP), pulmonary artery occlusion pressure (PAOP), cardiac index (CI), and the systemic vascular resistance index (SVRI) were repeatedly measured at the stages of preincision, postincision, poststernotomy, pericardium open, and 10 min after reperfusion.
Results: Although MAP after the sternotomy was increased compared with preincision, it remained within a normal range. Similarly, HR, mPAP, and PAOP were all within a normal range despite increases. The CI was within a normal range at all stages in both groups, and there were no significant difference between the two groups. In group I, the SVRI was significantly decreased compared with group II when pericardium was opened.
Conclusions: Both nicardipine and nitroglycerin were effective in preventing or attenuating hypertension after sternotomy with the hemodynamic stability. (Korean J Anesthesiol 2002; 42: 478∼486) Keyword : Heart; hemodynamics; nicardipine; nitroglycerin.
Alternative Title
The Effect of Preventive Antihypertensive Medication with Nicardipine or Nitroglycerin during Off-pump Coronary Artery Bypass Graft
Keimyung Author(s)(Kor)
홍지희
장영호
김진모
김애라
전재규
박원균
Publisher
School of Medicine
Citation
홍지희 et al. (2002). 체외순환 없는 관상동맥우회술시 고혈압 예방을 위한 Nicardipine 혹은 Nitroglycerin의 효과. 대한마취과학회지, 42(4), 478∼486-478∼486. doi: 10.4097/kjae.2002.42.4.478
Type
Article
ISSN
0302-5780
DOI
10.4097/kjae.2002.42.4.478
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/40129
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
1. School of Medicine (의과대학) > Dept. of Medical Education (의학교육학)
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