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할로탄 마취하 무호흡에 의한 혈역학 및 산소 이용률의 변화

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Author(s)
장영호정정길전재규송대규Young Ho JangJung Kil ChungJae Kyu CheunDae Kyu Song
Keimyung Author(s)
Jang, Young HoChung, Jung KilCheun, Jae KyuSong, Dae Kyu
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Dept. of Physiology (생리학)
Journal Title
대한마취과학회지
Issued Date
1998
Volume
34
Issue
2
Abstract
Background: Varying results of hemodynamic and oxygen parameters in response to hypoxia and/or hypercarbia have been reported. In this study, the effects of apnea on the hemodynamic parameters and oxygen availability were evaluated using ten healthy mongrel dogs.
Methods: After full oxygenation, apnea was induced by disconnecting animals from mechanical ventilation. Hemodynamic parameters, oxygen delivery, consumption and extraction ratio were measured at one minute intervals until the cardiac output was undetectable via the thermodilution method.
Results: Blood pressure(BP) increased continually following apnea. Cardiac output(CO) increased during the early of apnea(2 and 3 minute) but decreased thereafter. Systemic vascular resistance(SVR) decreased in the early phase of apnea but subsequently declined. The indices of preload increased steadily following apnea. Changes in heart rate(HR) were compared with changes in CO and oxygen delivery, and was found to increase during the early phase of apnea (2∼3 minutes) and decrease thereafter. The oxygen extraction ratio did not change significantly and remained steady 6 minutes after apnea but increased and became irregular thereafter.
Conclusions: These data suggest that early reflex responses such as increased BP were primarily due to increased CO, whereas the late increase in BP was due to the increase of SVR. We conclude that BP is not meaningful variables in evaluating critical hypoxic condition such as apnea, and bradycardia might be caused by decreased CO and severe hypoxemia. (Korean J Anesthesiol 1998; 34: 280∼293)
Key word : Hypoxia, Oxygen : consumption, Ventilation apnea.
Alternative Title
Changes in Hemodynamic and Oxygen Availability with Apnea under Halothane Anesthesia
Keimyung Author(s)(Kor)
장영호
정정길
전재규
송대규
Publisher
School of Medicine
Citation
장영호 et al. (1998). 할로탄 마취하 무호흡에 의한 혈역학 및 산소 이용률의 변화. 대한마취과학회지, 34(2), 280–293. doi: 10.4097/kjae.1998.34.2.280
Type
Article
ISSN
0302-5780
DOI
10.4097/kjae.1998.34.2.280
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/40136
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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