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Effect of A Kappa-opioid Receptor Agonist U50488H Given at Early Reperfusion Phase in Isolated Rat Hearts

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Author(s)
이용철장영호김진모김애라김찬진김윤년Yong Cheol LeeYoung Ho JangJin Mo KimAe Ra KimChan Jin KimYoon Nyun Kim
Keimyung Author(s)
Lee, Yong CheolJang, Young HoKim, Jin MoKim, Ae RaKim, Yoon Nyun
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Dept. of Internal Medicine (내과학)
Journal Title
대한마취과학회지
Issued Date
2008
Volume
54
Issue
3
Abstract
Background: The experiment was performed to determine the role of κ-opioid receptor (OR) agonist U50488H given at early reperfusion.
Methods: Isolated hearts were subjected to 30 minutes of regional ischemia and 120 minutes of reperfusion. Hearts were assigned randomly to one of the three groups: 1) Control (n = 9), 2) U50-1 (n = 8); 1μM of U50488H, and 3) U50-10 (n = 8); 10μM of U50488H. U50488 was perfused for a period of 5 min before and 30 min after reperfusion.
Results: U50488H significantly reduced infarct size as a percentage of ischemic area (12.2 ± 1.9% in U50-1 and 7.2 ± 1.7% in U50-10, P < 0.001) compared to the control hearts (27.2 ± 1.2%). After 2 hrs of reperfusion, left ventricular developed pressure was significantly recovered by U50488H (62.6 ± 5.7% in U50-1 and 68.6 ± 4.7% in U50-10, P = 0.018 and 0.002, respectively) compared to the control (46.3 ± 4.4%). Rate-pressure product was improved by 10μM U50488H (62.3 ± 5.5%, P = 0.007) but not by 1μM U50488H (50.0 ± 4.1%) compared to the control (44.7 ± 4.5%). U50488H significantly increased the +dP/dtmax (77.9 ± 5.5% in U50-1 and 78.0 ± 4.3 in U50-10, P = 0.005 and 0.001 vs. control, respectively). The −dP/dtmin also improved by 10μM U50488H (64.7 ± 4.8%, P = 0.003) compared to control (47.0 ± 2.7%).
Conclusions: U50488H given at early reperfusion phase reduces both infarct size and myocardial stunning in isolated rat hearts. (Korean J Anesthesiol 2008; 54: S 29∼34) Key Words: ischemia, myocardium, opioid receptor, reperfusion.
Alternative Title
흰쥐 적출 심장에서 재관류 시 투여한 카파 아편양수용체 작용제인 U50488H의 효과
Keimyung Author(s)(Kor)
이용철
장영호
김진모
김애라
김윤년
Publisher
School of Medicine
Citation
이용철 et al. (2008). Effect of A Kappa-opioid Receptor Agonist U50488H Given at Early Reperfusion Phase in Isolated Rat Hearts. 대한마취과학회지, 54(3), S29–S34. doi: 10.4097/kjae.2008.54.3.S29
Type
Article
ISSN
0302-5780
DOI
10.4097/kjae.2008.54.3.S29
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/40140
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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