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HL-60 세포주의 분화유도에 따른 IAP 유전자군의 발현

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Author(s)
백원기권택규박종욱서민호Won Ki BaekTaeg Kyu KwonJong Wook ParkMin Ho Suh
Keimyung Author(s)
Baek, Won KiSuh, Min HoKwon, Taeg KyuPark, Jong Wook
Department
Dept. of Microbiology (미생물학)
Dept. of Immunology (면역학)
Journal Title
Journal of Bacteriology and Virology
Issued Date
2003
Volume
33
Issue
1
Abstract
HL-60 cells (human promyelocytic leukemia cells) differentiate into the monocyte/macrophage like cells that die spontaneously by apoptosis when treated with 12-O-tetradecanoylphorbol-13-acetate (TPA). It is known that inhibitors of apoptosis proteins (IAP) bind to and inhibit caspase 3,7,9 activity and the induction of apoptosis. In this study, we examined the expression of IAP genes during TP A induced differentiation of HL-60 cells. During the differentiation, HIAP-1, HIAP-2, and XIAP expressions were decreased in protein levels. The pan-caspase inhibitor z-VAD-fmk blocked the decrease of HIAP-1 and HIAP-2, which indicates HIAP-1 and HIAP-2 could be caspase substrates. These findings suggest that the decrease of IAP proteins is related to the induction of apoptosis that is associated with TPA- induced HL-60 cell differentiation. Key Words: Differentiation, IAP, HL-60, Apoptosis
Alternative Title
Expression of IAP Genes During TPA-Induced Differentiation of HL-60 Cells
Keimyung Author(s)(Kor)
백원기
서민호
권택규
박종욱
Publisher
School of Medicine
Citation
백원기 et al. (2003). HL-60 세포주의 분화유도에 따른 IAP 유전자군의 발현. Journal of Bacteriology and Virology, 33(1), 113–118.
Type
Article
ISSN
1598-2467
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/40152
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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