계명대학교 의학도서관 Repository

인체대장암의 암유전자와 항암유전자의 분자유전적 특성 및 발현

Metadata Downloads
Author(s)
백원기서성일서민호Won Ki BaekSeong Il SuhMin Ho Suh
Keimyung Author(s)
Baek, Won KiSuh, Seong IlSuh, Min Ho
Department
Dept. of Microbiology (미생물학)
Institute for Medical Science (의과학연구소)
Journal Title
대한미생물학회지
Issued Date
1995
Volume
30
Issue
6
Abstract
To define the role of cellular oncogenes and tumor suppressor genes in human colorectal canc¬ers, genetic alterations of ras, myc, fos oncogenes and p53 antioncogene in 30 freshly isolated primary colorectal cancer tissues were studied by using various molecular methods. In Southern blot hybridization, modest amplifications of c-myc gene(40%) were found in cancer tissues but no amplification and rearrangement of c-Ha-ras, c-fos and p53 genes were observed. In RNA slot blot analysis, 47% of cases showed significantly elevated expression of c-myc gene and 12% of cases showed modest elevated level of c-Ha-ras gene transcripts. These results suggested that amplification/overexpression of c-myc gene and elevated expression of c-Ha-ras gene were involved in tumor development of Korean colorectal cancers.
Key Words: Colorectal cancer, ras, myc, fos, p53.
Alternative Title
Molecular Characteristics of Oncogenes and p53 Antioncogene in Korean Colorectal Cancers
Keimyung Author(s)(Kor)
백원기
서성일
서민호
Publisher
School of Medicine
Citation
백원기 et al. (1995). 인체대장암의 암유전자와 항암유전자의 분자유전적 특성 및 발현. 대한미생물학회지, 30(6), 727–735.
Type
Article
ISSN
0253-3162
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/40162
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.