임상가검물에서 최근 6년간 분리한 대장균의 항균제내성의 추이

Abstract

Escherichia coli ranks very high among bacteria isolated from clinical specimens. From 1987 to 1992, E. coli isolated from various clinical specimens were tested for resistance to antimicrobial drugs. Most of the strains tested were susceptible to quinolone carboxylic acid compounds (QA), moxalactam (Mx), amikacin (Ak), and rifampin (Rf), but other drugs tested showed very low antimicrobial activities against the majority of strains. Especially, resistance frequency of EL coli against cephalothin, cefamandᄋle, and gentamicin have been increased gradually during last 6 years. 90% MIC of drugs tested were very high except QA, Mx, Ak and Rf and over 50% of or¬ganisms multiflying resistance to 6 or more drugs were noted. Of importance has been the stead¬ily increasing resistance of E. coli to many antibiotics from 1987 to present. However, reversal of these trends of antimicrobial resistance may result from more specifically directed choices of drugs for infectious diseases, reduction in the excessive uses of antibiotics, the use of more ra¬tional dosage regimens, and discontinuance of general and routine antibiotic prophylactic regi¬mens in hospitals. Key Words : Escherichia coli，Multiple drug resistance.