계명대학교 의학도서관 Repository

임상재료에서 분리한 각종세균의 항균제내성

Metadata Downloads
Author(s)
서성일박종욱전도기Seong Il SuhJong Wook ParkDoki Chun
Keimyung Author(s)
Suh, Seong IlChun, Do kiPark, Jong Wook
Department
Dept. of Microbiology (미생물학)
Dept. of Immunology (면역학)
Journal Title
대한미생물학회지
Issued Date
1987
Volume
22
Issue
3
Abstract
One hundred and fifty-seven strains of staphylococci isolated from various clinical specimens and 80 of Gram-negative bacilli from urine of patients with urological diseases were tested for resistance to antimicrobial drugs by microdilution broth method.
Among staphylococci, 50 to 89% of the strains were resistant to gentamicin(Gm), kanamycin(Km), erythromycin (Em), nalidixic acid(Na), and tetracycline. Ninety per cent MIC was lowest in ciproflox¬acin (Cp), followed by vancomycin(Vc), trimethoprim(Tp), enoxacin(Ex), and norfloxacin (Nf), with the values of two ;ug/ml or lower. Twenty-seven strains were resistant to methicillin(MR), with 24 strains of Staphylococcus aureus and 3 of S. epidermidis. All strains of MR S. aureus were resistant to oxacil¬lin, rifampin(Rf), Gm, Km, Em, Na, and Tc, and no strain was resistant to Vc and Tp. Almost all st¬aphylococci isolated from urine were S. epidermidis and sensitive to most drugs tested without MR strain.
Among Gram-negative bacilli from urine, Escherichia c/>.(10), and Pseudomonas aeruginosa (6) in the decreasing order. The majority of E. coli and Serratia spp. were resistant to chloramphenicol (Cm), Tc, streptomycin, sulfisomidine(Su), ampicillin(Ap), Km, and carbenicillin(Cb), and 50 and 90% MICs of these drugs were also high. In Klebsiella spp., 54% or more were resistant to Cm, Su, Ap, cephalothin, and Cb. Proteus spp. were susceptible to most drugs tested, but Pseudomonas were resis¬tant to nearly all drugs tested except Rf, amikacin, and moxalactam(Mx). All Gram-negative bacilli tes¬ted were found to be susceptible to Mx.
New quinolone carboxylic acid compounds,such as Nf, Ex, and Cp showed very high antimicrobial activities against the majority of organisms tested except Pseudomonas, and 50 and 90% MICs of Nf and Ex were always equal or 2 to 4 times higher than Cp.
Organisms multiply resistant to drugs were noted in almost all isolates tested. Twenty-seven strains of staphylococci were multiply resistant to 11 or more drugs, and 6 of Klebsiella spp. to 8 to 11 drugs. The most frequent multiplicity of durg resistance were 7 and 8, 12, and 13 in E. colt, Serratia spp., and Pseudomonas, respectively. No strain was resistant to more than 5 drugs in Proteus spp..
Key Words: Drug resistance.
Alternative Title
Anitimicrobial Resistance of Organisms Isolated from Clinical Specimens
Keimyung Author(s)(Kor)
서성일
전도기
박종욱
Publisher
School of Medicine
Citation
서성일 et al. (1987). 임상재료에서 분리한 각종세균의 항균제내성. 대한미생물학회지, 22(3), 283–294.
Type
Article
ISSN
0253-3162
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/40170
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.