계명대학교 의학도서관 Repository

Cyto-Molecular Comparison Between Human Primary Cancer and its Derived Cancer Cell Line

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Author(s)
장성익김대광김홍태이인환최인장
Keimyung Author(s)
Chang, Sung IkKim, Dae KwangLee, In HwanChoi, In Jang
Department
Dept. of Anatomy (해부학)
Institute for Medical Science (의과학 연구소)
Journal Title
Keimyung Medical Journal
Issued Date
1997
Volume
16
Issue
4
Keyword
Cyto-molecularAbnormalitiesHypotetraploidUrinary bladder
Abstract
In order to evaluate which
cyto-molecular genetic evolutionary patterns take place during the in vitro establishment of permant squamous cell carcinoma cell line of urinary bladder; cyto-molecular genetic follow up was performed on primary culture for two weeks and on cancer cell line after continued culture for three years in vitro. Near-diploid cells present on primary culture and near-hypertriploid or hypotetraploid cells; in contrast; present on cancer cell line. Chromosomal gains or losses are random from primary cancer to cancer cell line. There are two kinds of structural cytogenetic abnormalities through progress in culture time. One is maintaining abnormal clone from original cancer to derived cancer cell line. Others are cytogenetic alteration; In creasing and decreasing abnormal clones are co-existed in both group. Activations of oncogenes are different from primary cancer to cancer cell line. It is concluded that the eventual chromosomal compositions of squamous cell carcinoma of bladder derived cell line are the production of cyto-mo3ecuJar evolutions from original tumor.
Alternative Title
Cyto-Molecular Comparison Between Human Primary Cancer and its Derived Cancer Cell Line
Keimyung Author(s)(Kor)
장성익
김대광
이인환
최인장
Publisher
Keimyung University School of Medicine
Citation
장성익 et al. (1997). Cyto-Molecular Comparison Between Human Primary Cancer and its Derived Cancer Cell Line. Keimyung Medical Journal, 16(4), 471–484.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/40222
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1997
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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