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일개 대학병원에서 분리된 반코마이신내성 장구균의 분자역학적 분석

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Author(s)
이원목김지혜하정숙류남희전동석김재룡이위교
Keimyung Author(s)
Lee, Won MokHa, Jung SookRyoo, Nam HeeJeon, Dong SeokKim, Jae Ryong
Department
Dept. of Laboratory Medicine (진단검사의학)
Journal Title
Keimyung Medical Journal
Issued Date
2008
Volume
27
Issue
1
Keyword
Pulsed field gel electrophoresisvanAVancomycin-resistant enterococci
Abstract
Since the first report of vancomycin-resistant enterococci (VRE) in 1992; the
prevalence of VRE in the hospitals has rapidly increased in Korea. VRE have emerged as a major
cause of nosocomial infections. The aims of present study were to determine the prevalence of
VRE; the genotype of VRE and to establish whether the isolates were clonally related. A total of
90 VRE isolates were collected from the patients admitted to Dongsan Medical Center from Jan to
Dec; 2006. Species identification and genotyping were evaluated with multiplex polymerase chain
reaction. Antimicrobial susceptibility test was determined by agar dilution methods according to
Clinical and Laboratory Standards Institute (CLSI). Pulsed field gel electrophoresis (PFGE) with
SmaI-restriction enzyme was also performed. The annual incidence of VRE was 16.2% in 2001;
19.4% in 2002; 16% in 2003; 23.7% in 2004; 24.7% in 2005 and 14.7% in 2006. VRE were
identified as E. faecium and E. faecalis in 71 (78.9%) and 19 (21.1%) isolates; respectively. All
VRE isolates were resistant to vancomycin. Only 75 VRE isolates were resistant to teicoplanin;
and 15 VRE isolates were susceptible or intermediate to teicoplanin which were interpreted as
VanB phenotypes. All VRE isolates carried the vanA gene. PFGE analysis showed that all 15 VRE.
faecalis from the nursery showed same patterns. Our data indicate that the annual prevalence of
VRE seems to decrease shortly but should surveil continuously afterward. VRE isolates of the
nursery that showed same PFGE pattern is probably due to the spread of an endemic clone within
the hospital. Therefore; further moleculoepidemiological evaluations would be needed
prospectively.
Alternative Title
Moleculoepidemiological Analysis of Vancomycin-Resistant Enterococci Isolated from
a Tertiary Care Hospital
Keimyung Author(s)(Kor)
이원목
하정숙
류남희
전동석
김재룡
Publisher
Keimyung University School of Medicine
Citation
이원목 et al. (2008). 일개 대학병원에서 분리된 반코마이신내성 장구균의 분자역학적 분석. Keimyung Medical Journal, 27(1), 41-48-41–48.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/40264
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2008
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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