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Diagnostic accuracy of urinary biomarkers in infants younger than 3 months with urinary tract infection

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Author(s)
Nani JungHye Jin ByunJae Hyun ParkJoon Sik KimHae Won KimJi Yong Ha
Keimyung Author(s)
Kim, Joon SikKim, Hae WonHa, Ji YongPark, Jae Hyun
Department
Dept. of Pediatrics (소아청소년학)
Dept. of Nuclear Medicine (핵의학)
Dept. of Urology (비뇨의학)
Journal Title
Korean Journal of Pediatrics
Issued Date
2018
Volume
61
Issue
1
Keyword
Urinary tract infectionBiomarkersNeutrophil gelatinase-associated lipocalin
Abstract
Purpose: The aim of this study was to evaluate the diagnostic accuracy of urinary biomarkers, such as
neutrophil gelatinase-associated lipocalin (uNGAL) and β-2 microglobulin (uB2MG), in early detection of
urinary tract infection (UTI) in infants aged <3 months with fever.
Methods: A total of 422 infants aged <3 months (male:female=267:155; mean age, 56.4 days), who
were admitted for fever, were retrospectively included in this study. We compared uNGAL and uB2MG
between the UTI and non-UTI groups at the time of admission. The sensitivity, specificity, accuracy, and
area under the curve (AUC) of uNGAL and uB2MG for use in diagnosing UTI were assessed.
Results: Among 422 patients, 102 (24.2%) were diagnosed with UTI. Levels of uNGAL were higher in the
UTI group than in the non-UTI group (366.6 ng/mL vs. 26.9 ng/mL, P<0.001). Levels of uB2MG were not
different between the 2 groups. Multivariate analysis revealed that uNGAL was an independent predictive
factor for UTI (P=0.033). The sensitivity, specificity, and accuracy were 90.2%, 92.5%, and 91.9% for
uNGAL, and 48.0%, 43.8%, and 44.8% for uB2MG, respectively. AUC of uNGAL was 0.942 and that of
uB2MG was 0.407.
Conclusion: Accuracy of uNGAL in the diagnosis of UTI is high in febrile infants aged <3 months. uNGAL
can help in the early diagnosis and treatment of UTI in infants.
Keimyung Author(s)(Kor)
김준식
김해원
하지용
박재현
Publisher
School of Medicine (의과대학)
Citation
Nani Jung et al. (2018). Diagnostic accuracy of urinary biomarkers in infants younger than 3 months with urinary tract infection. Korean Journal of Pediatrics, 61(1), 24–29. doi: 10.3345/kjp.2018.61.1.24
Type
Article
ISSN
1738-1061
DOI
10.3345/kjp.2018.61.1.24
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41027
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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