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A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

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Author(s)
Qixuan WangJi Won OhHye-Lim LeeAnukriti DharTao PengRaul RamosChristian Fernando Guerrero-JuarezXiaojie WangRan ZhaoXiaoling CaoJonathan LeMelisa A FuentesShelby C JocoyAntoni R RossiBrian VuKim PhamXiaoyang WangNanda Maya MaliJung Min ParkJune-Hyug ChoiHyunsu LeeJulien M D LegrandEve KandybaJung Chul KimMoonkyu KimJohn FoleyZhengquan YuKrzysztof KobielakBogi AndersenKiarash KhosrotehraniQing NieMaksim V Plikus
Keimyung Author(s)
Lee, Hyun Su
Department
Dept. of Anatomy (해부학)
Journal Title
eLife
Issued Date
2017
Volume
6
Keyword
computational biologydevelopmental biologyhair folliclemousepattern formationskinstem cellssystems biology
Abstract
The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and experimental data reveal that mouse skin behaves as a heterogeneous regenerative field, composed of anatomical domains where HFs have distinct cycling dynamics. Interactions between fast-cycling chin and ventral HFs and slow-cycling dorsal HFs produce bilaterally symmetric patterns. Ear skin behaves as a hyper-refractory domain with HFs in extended rest phase. Such hyper-refractivity relates to high levels of BMP ligands and WNT antagonists, in part expressed by ear-specific cartilage and muscle. Hair growth stops at the boundaries with hyper-refractory ears and anatomically discontinuous eyelids, generating wave-breaking effects. We posit that similar mechanisms for coupled regeneration with dominant activator, hyper-refractory, and wave-breaker regions can operate in other actively renewing organs.
Keimyung Author(s)(Kor)
이현수
Publisher
School of Medicine (의과대학)
Citation
Qixuan Wang et al. (2017). A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning. eLife, 6, e22772–e22772. doi: 10.7554/eLife.22772.
Type
Article
ISSN
2050-084X
DOI
10.7554/eLife.22772.
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41035
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
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